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CG 1521

Known as: CG-1521, CG1521 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment
Background The efficacy of epigenetic drugs, such as histone deacetylase inhibitors, is often diminished by poor aqueous… 
2016
2016
Berberine acts as a putative epigenetic modulator by affecting the histone code.
2015
2015
Gcn5 Modulates the Cellular Response to Oxidative Stress and Histone Deacetylase Inhibition
To identify chemical genetic interactions underlying the mechanism of action of histone deacetylase inhibitors (HDACi) a yeast… 
2014
2014
High throughput screening identifies modulators of histone deacetylase inhibitors
Previous studies from our laboratory and others have demonstrated that in addition to altering chromatin acetylation and… 
2013
2013
Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells
To develop new therapies for inflammatory breast cancer (IBC) we have compared the effects of two hydroxamic acid-based histone… 
2011
2011
Comparative effects of histone deacetylase inhibitors on p53 target gene expression, cell cycle and apoptosis in MCF-7 breast cancer cells.
Histone deacetylase inhibitors are currently being evaluated for their therapeutic potential and have shown… 
2010
2010
Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy.
2008
2008
Comparative molecular dynamics simulations of histone deacetylase‐like protein: Binding modes and free energy analysis to hydroxamic acid inhibitors
Histone deacetylases (HDACs) play an important role in gene transcription, and inhibitors of HDACs can induce cell… 
Highly Cited
2007
Highly Cited
2007
Site-specific Acetylation of p53 Directs Selective Transcription Complex Assembly*
Histone deacetylase (HDAC) inhibitors are being investigated as possible adjuvant therapies for a number of diseases, including… 
Highly Cited
2005
Highly Cited
2005
Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells
In LNCaP prostate cancer cells CG-1521, a new inhibitor of histone deacetylases, alters the acetylation of p53 in a site-specific… 
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