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CFHR4 gene

Known as: COMPLEMENT FACTOR H-RELATED 4, FHR4, CFHR4 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are… 
2018
2018
Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic… 
2018
2018
Setting the scale: The balance between complement factor H and its related proteins in health and disease
Complement is a crucial part of innate immunity and consists of proteins that circulate in blood and protect the body against… 
2015
2015
A novel CD46 mutation in a patient with microangiopathy clinically resembling thrombotic thrombocytopenic purpura and normal ADAMTS13 activity
The differential diagnosis and etiological classification of the two main forms of thrombotic microangiopathy (TMA) [thrombotic… 
Highly Cited
2012
Highly Cited
2012
Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein
Background: Complement factor H-related protein 4 (CFHR4) has been shown to interact with C3b. Results: Binding of C3b to CFHR4… 
2012
2012
Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS
Highly Cited
2012
Highly Cited
2012
A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.
Genomic disorders affecting the genes encoding factor H (fH) and the 5 factor H related proteins have been described in… 
2010
2010
Preparation and identification of antibodies against FHR4
We aimed to prepare rabbit polyclonal and mouse monoclonal antibodies(mAbs) against human FHR4 and characterize these antibodies… 
Highly Cited
2005
Highly Cited
2005
FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene
We describe a new member of the human Factor H protein family, termed Factor H-related protein 4A (FHR-4A). The corresponding… 
Highly Cited
1998
Highly Cited
1998
Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins.
The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds… 
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