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CFHR4 gene

Known as: COMPLEMENT FACTOR H-RELATED 4, FHR4, CFHR4 
 
National Institutes of Health

Papers overview

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2018
2018
Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.
PURPOSE To identify genetic variants associated with complement activation, which may help to select age-related macular… Expand
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2018
2018
Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are… Expand
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Highly Cited
2012
Highly Cited
2012
Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein
Background: Complement factor H-related protein 4 (CFHR4) has been shown to interact with C3b. Results: Binding of C3b to CFHR4… Expand
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2012
2012
Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS
Highlights ► Hypothesis tested: common sequence variants in complement are associated with aHUS. ► SNPs in complement genes were… Expand
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Highly Cited
2012
Highly Cited
2012
A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.
Genomic disorders affecting the genes encoding factor H (fH) and the 5 factor H related proteins have been described in… Expand
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2011
2011
Copy number variation in the complement factor H-related genes and age-related macular degeneration
Purpose To determine the contribution of copy number variation (CNV) in the regulation of complement activation (RCA) locus to… Expand
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Highly Cited
2010
Highly Cited
2010
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and… Expand
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Highly Cited
2005
Highly Cited
2005
FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene
We describe a new member of the human Factor H protein family, termed Factor H-related protein 4A (FHR-4A). The corresponding… Expand
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Highly Cited
1999
Highly Cited
1999
Functional properties of complement factor H‐related proteins FHR‐3 and FHR‐4: binding to the C3d region of C3b and differential regulation by heparin
The human factor H‐related proteins FHR‐3 and FHR‐4 are members of a family of proteins related to the complement factor H. Here… Expand
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Highly Cited
1998
Highly Cited
1998
Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins.
The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds… Expand
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