Skip to search formSkip to main contentSkip to account menu
You are currently offline. Some features of the site may not work correctly.

CFHR4 gene

Known as: COMPLEMENT FACTOR H-RELATED 4, FHR4, CFHR4 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.
PURPOSE To identify genetic variants associated with complement activation, which may help to select age-related macular… Expand
  • table 1
  • figure 1
  • figure 3
  • table 6
  • table 7
2018
2018
Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are… Expand
Highly Cited
2012
Highly Cited
2012
Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein
Background: Complement factor H-related protein 4 (CFHR4) has been shown to interact with C3b. Results: Binding of C3b to CFHR4… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2012
2012
Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS
Highlights ► Hypothesis tested: common sequence variants in complement are associated with aHUS. ► SNPs in complement genes were… Expand
Highly Cited
2012
Highly Cited
2012
A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.
Genomic disorders affecting the genes encoding factor H (fH) and the 5 factor H related proteins have been described in… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
2011
2011
Copy number variation in the complement factor H-related genes and age-related macular degeneration
Purpose To determine the contribution of copy number variation (CNV) in the regulation of complement activation (RCA) locus to… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Highly Cited
2010
Highly Cited
2010
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Highly Cited
2005
Highly Cited
2005
FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene
We describe a new member of the human Factor H protein family, termed Factor H-related protein 4A (FHR-4A). The corresponding… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Highly Cited
1999
Highly Cited
1999
Functional properties of complement factor H‐related proteins FHR‐3 and FHR‐4: binding to the C3d region of C3b and differential regulation by heparin
The human factor H‐related proteins FHR‐3 and FHR‐4 are members of a family of proteins related to the complement factor H. Here… Expand
Highly Cited
1998
Highly Cited
1998
Identification of a domain in human factor H and factor H-like protein-1 required for the interaction with streptococcal M proteins.
The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE