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To identify genetic variants associated with complement activation, which may help to select age-related macular… Expand Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are… Expand Background: Complement factor H-related protein 4 (CFHR4) has been shown to interact with C3b. Results: Binding of C3b to CFHR4… Expand Highlights ► Hypothesis tested: common sequence variants in complement are associated with aHUS. ► SNPs in complement genes were… Expand Genomic disorders affecting the genes encoding factor H (fH) and the 5 factor H related proteins have been described in… Expand Purpose To determine the contribution of copy number variation (CNV) in the regulation of complement activation (RCA) locus to… Expand Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and… Expand We describe a new member of the human Factor H protein family, termed Factor H-related protein 4A (FHR-4A). The corresponding… Expand The human factor H‐related proteins FHR‐3 and FHR‐4 are members of a family of proteins related to the complement factor H. Here… Expand The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds… Expand