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CERS6 gene

Known as: CERAMIDE SYNTHASE 6, CERS6, LASS6 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
A 19-Gene expression signature as a predictor of survival in colorectal cancer
Histopathological assessment has a low potential to predict clinical outcome in patients with the same stage of colorectal cancer… 
Highly Cited
2013
Highly Cited
2013
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Highly Cited
2011
Highly Cited
2011
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism[S]
Mammalian ceramide synthases 1 to 6 (CerS1–6) generate Cer in an acyl-CoA-dependent manner, and expression of individual CerS has… 
Highly Cited
2011
Highly Cited
2011
Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi…
Background: Mechanisms of ATF-6 activation and apoptosis by CerS6/C16-ceramide knockdown remain unknown. Results: ATF-6 was… 
Highly Cited
2010
Highly Cited
2010
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
Highly Cited
2010
Highly Cited
2010
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
The targeted therapeutics sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by activating CD95… 
Highly Cited
2010
Highly Cited
2010
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
Highly Cited
2008
Highly Cited
2008
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells
We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces… 
Highly Cited
2006
Highly Cited
2006
The CLN9 Protein, a Regulator of Dihydroceramide Synthase*
A new variant of a group of pediatric neurodegenerative diseases known as neuronal ceroid lipofuscinosis (NCL) or Batten disease… 
Highly Cited
2005
Highly Cited
2005
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide… 
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