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CDPPB

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding
As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug… 
2018
2018
Metabotropic glutamate receptor modulation of dopamine release in the nucleus accumbens shell is unaffected by phencyclidine pretreatment: In vitro assessment using fast-scan cyclic voltammetry rat…
2015
2015
mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex.
Positive and negative allosteric modulators (PAMs and NAMs, respectively) of type 5 metabotropic glutamate receptors (mGluR5) are… 
2014
2014
Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors.
In rat prefrontal cortex (PFC), long-term depression induced by low-frequency single stimuli has never been studied. Combined… 
2014
2014
The mGluR5 Positive Allosteric Modulator CDPPB Inhibits SO2-Induced Protein Radical Formation and Mitochondrial Dysfunction Through Activation of Akt in Mouse Hippocampal HT22 Cells
Sulfur dioxide (SO2) is a common gas pollutant that is detrimental to many organs. Previous studies have shown that SO2 exposure… 
2013
2013
Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine
We investigated the role of metabotropic glutamate receptor type 5 (mGluR5) in methamphetamine-induced behavioral sensitization… 
2013
2013
Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents
Metabotropic glutamate receptor 5 (mGlu5) has been implicated in a variety of learning processes and is important for aversive… 
2012
2012
Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test
Review
2011
Review
2011
Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
This Review describes recent trends in the development of small molecule mGlu(5) positive allosteric modulators (PAMs). A large… 
2011
2011
The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats.
Extinction of drug-seeking behavior is a form of new and active learning. Facilitation of extinction learning is of clinical… 
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