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CDK19 gene

Known as: KIAA1028, CDK19, bA346C16.3 
National Institutes of Health

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1 relation

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC
The Mediator complex is a central integrator of transcription and a hub for the regulation of gene expression. Cyclin dependent… 
2019
2019
Pharmacological retraining for T cells
Immune Regulation Regulatory T cells (Tregs) expressing the Foxp3 transcription factor play a critical role in dampening… 
2019
2019
Targeting mediator subunits CDK8/CDK19 for treatment of advanced prostate cancer.
152 Background: The mediator complex plays a pivotal role in the regulation of gene transcription. The subunits CDK8 and CDK19… 
2017
2017
CDK8: a new breast cancer target
Close to 70% of all breast cancers express the estrogen receptor (ER), one of the oldest molecular targets in oncology. Once ER… 
2017
2017
Abstract 4896: Role of CDK8 in colon cancer hepatic metastasis
About half of all colon cancer patients will develop liver metastases and the 5-year survival for these patients is less than 13… 
2017
2017
Abstract 129: Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19
2016
2016
Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential
Background The Mediator complex-associated kinases CDK8 and CDK19 are cyclin C-dependent enzymes that, with MED12 and MED13, form… 
2016
2016
Abstract P5-04-07: CDK8 protein complex as a potential biomarker and therapeutic target in breast cancer
Cyclin-dependent kinase 8 (CDK8) and its paralog CDK19 are transcriptional regulators that, in complex with CCNC, MED12 and MED13… 
2015
2015
Abstract 5459: Overcoming resistance to HER2-targeting drugs using CDK8 inhibitors
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA HER2-targeting therapies transformed the… 
2014
2014
Abstract 616: Transcription-regulating kinases CDK8 and CDK19 as novel therapeutic targets for advanced prostate cancer
Most of castration-refractory prostate cancers (CRPC) continue to express androgen receptor (AR) that maintains its activity at… 
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