FAQ

CD95 death-inducing signaling complex

Known as: CD95 death-inducing signalling complex, Fas death-inducing signaling complex location, CD95 death-inducing signalling complex location 
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2016
024619962016

Papers overview

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Highly Cited
2012
Highly Cited
2012
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.
The CD95 (Fas/APO-1) death-inducing signaling complex (DISC) is essential for the initiation of CD95-mediated apoptotic and… (More)
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Highly Cited
2010
Highly Cited
2010
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells
This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell… (More)
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2006
2006
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis.
Caspase-2 was reported to be involved in a number of apoptotic pathways triggered by various stimuli. However, the molecular… (More)
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2004
2004
CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.
We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and… (More)
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Highly Cited
2002
Highly Cited
2002
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis.
Activation of the caspase cascade is a pivotal step in apoptosis and can occur via death adaptor-mediated homo-oligomerization of… (More)
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Highly Cited
2002
Highly Cited
2002
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
The involvement of the death adaptor protein FADD and the apoptosis-initiating caspase-8 in CD95 and TRAIL death signalling has… (More)
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Highly Cited
2001
Highly Cited
2001
Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex.
Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1, procaspase-8, and the cellular FLICE-inhibitory… (More)
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Highly Cited
2001
Highly Cited
2001
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
Resistance of tumors to treatment with cytotoxic drugs, irradiation or immunotherapy may be due to disrupted apoptosis programs… (More)
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Highly Cited
1999
Highly Cited
1999
The role of c-FLIP in modulation of CD95-induced apoptosis.
Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule Fas-associated death domain protein (FADD)/MORT1 and caspase-8… (More)
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Highly Cited
1997
Highly Cited
1997
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).
Upon activation, the apoptosis-inducing cell membrane receptor CD95 (APO-1/Fas) recruits a set of intracellular signaling… (More)
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