CD95 death-inducing signaling complex

Known as: CD95 death-inducing signalling complex, Fas death-inducing signaling complex location, CD95 death-inducing signalling complex location 
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2016
024619962016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The CD95 (Fas/APO-1) death-inducing signaling complex (DISC) is essential for the initiation of CD95-mediated apoptotic and… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2006
2006
Caspase-2 was reported to be involved in a number of apoptotic pathways triggered by various stimuli. However, the molecular… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2004
2004
We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Activation of the caspase cascade is a pivotal step in apoptosis and can occur via death adaptor-mediated homo-oligomerization of… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The involvement of the death adaptor protein FADD and the apoptosis-initiating caspase-8 in CD95 and TRAIL death signalling has… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1, procaspase-8, and the cellular FLICE-inhibitory… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Resistance of tumors to treatment with cytotoxic drugs, irradiation or immunotherapy may be due to disrupted apoptosis programs… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule Fas-associated death domain protein (FADD)/MORT1 and caspase-8… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Upon activation, the apoptosis-inducing cell membrane receptor CD95 (APO-1/Fas) recruits a set of intracellular signaling… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?