CD2AP gene

We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing… (More)

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using… (More)

Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular diagnosis resulting in end-stage renal disease… (More)

The bacterial pathogen Listeria monocytogenes uses the surface protein InlB to invade a variety of cell types. The interaction of… (More)

Mutations of NPHS1 or NPHS2, the genes encoding nephrin and podocin, as well as the targeted disruption of CD2-associated protein… (More)

Loss of CD2-associated protein (CD2AP), a component of the filtration complex in the kidney, causes death in mice at 6 weeks of… (More)

Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for modulating their activity. Upon ligand… (More)

Recent molecular insights have established the podocyte as a key component of the glomerular filtration barrier, and hence an… (More)

NPHS2 was recently identified as a gene whose mutations cause autosomal recessive steroid-resistant nephrotic syndrome. Its… (More)

CD2AP, an adapter protein containing multiple SH3 domains, plays a critical role in kidney function. Mice lacking CD2AP die soon… (More)