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CCR4-NOT complex

Known as: CCR4-NOT complex location 
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA… 
National Institutes of Health

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CCR4-NOT core complex

Papers overview

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2020
2020
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability
ABSTRACT Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase… 
2017
2017
Mutations in the NOT Genes or in the Translation Machinery Similarly Display Increased Resistance to Histidine Starvation
The NOT genes encode subunits of the conserved Ccr4-Not complex, a global regulator of gene expression, and in particular of mRNA… 
Highly Cited
2017
Highly Cited
2017
A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target degradation through the recruitment of the CCR4… 
2016
2016
CCR4 and CAF1 deadenylases have an intrinsic activity to remove the post-poly(A) sequence
MicroRNAs (miRNAs) recruit the CCR4–NOT complex, which contains two deadenylases, CCR4 and CAF1, to promote shortening of the… 
2015
2015
Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast
Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast… 
Highly Cited
2014
Highly Cited
2014
Structural basis for the Nanos-mediated recruitment of the CCR4–NOT complex and translational repression
Nanos family RNA-binding proteins play essential roles in metazoan germ cell fate and survival, yet the underlying mechanism has… 
Review
2014
Review
2014
Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation
The CCR4-NOT complex is a highly conserved specific gene silencer that also serves more general post-transcriptional functions… 
Highly Cited
2013
Highly Cited
2013
C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex
The CCR4-NOT complex was originally identified and its composition and organization characterized in the yeast Saccharomyces… 
Review
2010
Review
2010
The structural basis for deadenylation by the CCR4-NOT complex
The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been… 
Highly Cited
2001
Highly Cited
2001
Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.
The CCR4-NOT complex is involved in the regulation of gene expression both positively and negatively. The repressive effects of… 
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