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3M syndrome is characterized by severe pre‐ and postnatal growth retardation, typical facial features, and normal intelligence… Expand BackgroundTumour metastasis to the brain is a common and deadly development in certain cancers; 18–30 % of breast tumours… Expand Peptide motifs are often used for protein-protein interactions. We have recently demonstrated that ankyrin repeats of ANKRA2 and… Expand CUL7, OBSL1, and CCDC8 genes are mutated in a mutually exclusive manner in 3M and other growth retardation syndromes. The… Expand Mutations in CUL7, OBSL1 and CCDC8, leading to disordered ubiquitination, cause one of the commonest primordial growth disorders… Expand 3-M syndrome is a primordial growth disorder caused by mutations in CUL7, OBSL1 or CCDC8. 3-M patients typically have a modest… Expand 3‐M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post‐natal growth… Expand 3-M syndrome, a primordial growth disorder, is associated with mutations in CUL7 and OBSL1. Exome sequencing now identifies… Expand The detection of promoter region hypermethylation and transcriptional silencing has facilitated the identification of candidate… Expand 3-M syndrome is an autosomal recessive primordial growth disorder characterised by severe postnatal growth restriction caused by… Expand