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BackgroundColon cancer (CC) cells can exhibit stemness and expansion capabilities, which contribute to resistance to conventional… Expand The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent… Expand Chromatin-mediated processes influence the development and progression of breast cancer. Using murine mammary carcinoma-derived… Expand Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China… Expand Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem… Expand The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that… Expand The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is often found deregulated in human… Expand ABSTRACT The chromodomain (CD) of the Drosophila Polycomb protein exhibits preferential binding affinity for histone H3 when… Expand The translocation t(11;19) is frequently found in acute leukemia in infants. This event truncates the proto-oncogene MLL and… Expand Polycomb group (PcG) proteins were first described in Drosophila as factors responsible for maintaining the transcriptionally… Expand