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CBP/beta-catenin Antagonist PRI-724

Known as: PRI-724 
A potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice
Abstract Purpose/Aim of the Study: Wnt/β-catenin signaling was reported to be activated in pulmonary fibrosis, and was focused on… 
2019
2019
miR-601 inhibits proliferation, migration and invasion of prostate cancer stem cells by targeting KRT5 to inactivate the Wnt signaling pathway.
OBJECTIVE This study aimed to verify the hypothesis that downregulation of miR-601 inhibits the proliferation, migration, and… 
2019
2019
Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers
ABSTRACT Immune checkpoint blockade with specific antibodies can accelerate anti-tumor immunity, resulting in clinical responses… 
2019
2019
HER2 Regulates Cancer Stem Cell Activities via the Wnt Signaling Pathway in Gastric Cancer Cells
Introduction: Human epidermal growth factor 2 (HER2) gene overexpression in breast carcinoma cell lines has been shown to drive… 
Review
2017
Review
2017
Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… 
Highly Cited
2017
Highly Cited
2017
Combined inhibition of β-catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation… 
Review
2017
Review
2017
Therapeutic strategies against cancer stem cells in human colorectal cancer
Colorectal cancer (CRC) is the third most frequent malignancy and represents the fourth most common cause of cancer-associated… 
Highly Cited
2015
Highly Cited
2015
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
Review
2014
Review
2014
Safely targeting cancer stem cells via selective catenin coactivator antagonism
Throughout our life, long‐lived somatic stem cells (SSC) regenerate adult tissues both during homeostatic processes and repair… 
Highly Cited
2013
Highly Cited
2013
A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors.
2501 Background: PRI-724 is a first-in-class modulator of Wnt signaling that inhibits the CREB binding protein and β-catenin… 
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