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CB 10277

Known as: CB 10-277, CB-10277, CB10-277 
A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277… 
National Institutes of Health

Papers overview

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2004
2004
In vivo depletion of O6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue
Summarythere is increasing evidence to suggest that alkylation of guanine residues in DNA at the O6 position is the critical… 
1994
1994
Relationships between the formation of O6-methyldeoxyguanosine by 1-p-carboxyl-3,3-dimethylphenyltriazene in DNA and O6-alkylguanine-DNA alkyltransferase in human peripheral leukocytes.
There is increasing experimental evidence to indicate that O6-methyldeoxyguanosine (O6-MedG) formation in DNA is a critical… 
1993
1993
Formation and loss of 06-methyldeoxyguanosine (06-MedG) in peripheral leukocytes of patients receiving dacarbazine (DTIC) or CB 10-277.
1990
1990
Clinical Studies with the p-Carboxyl Dimethyl Phenyl Triazene CB10-277
Analogue development is one of the undoubted success stories of cancer chemotherapy. For example, there are many analogues of the… 
1988
1988
Third Annual Meeting of the Association of Cancer Physicians—22/24 March 1988. Abstracts of the proceedings
s of Members' Proffered Papers Oral Presentations The use of megace in advanced breast cancer J.R.F. Robertson, M.R. Williams, D… 
1988
1988
PRECLINICAL AND CLINICAL PHARMACOKINETIC STUDIES WITH 1-(4-CARBOXYPHENYL)-3, 3-DIMETHYL TRIAZENE (CB10-277)
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