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CAIX Inhibitor DTP348

Known as: 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide, DTP348 
An orally bioavailable, nitroimidazole-based sulfamide, carbonic anhydrase IX (CAIX) inhibitor with potential antineoplastic activity. Upon… 
National Institutes of Health

Papers overview

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2018
2018
Abstract Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has… 
Highly Cited
2015
Highly Cited
2015
Triple negative, resistant or metastatic disease are major factors in breast cancer mortality, warranting novel approaches… 
2015
2015
To test the hypothesis that the hypoxia marker carbonic anhydrase IX (CAIX), and the cholangiocytic/progenitor markers… 
2013
2013
ABSTRACT To survive in various environments, from host tissue to soil, opportunistic bacterial pathogens must be metabolically… 
Highly Cited
2011
Highly Cited
2011
PurposeAs hypoxia is believed to play an important role in the development and progression of prostate cancer, we evaluated… 
2010
2010
Carbonic anhydrase IX (CAIX, gene G250/MN-encoded transmembrane protein) is highly expressed in various human epithelial tumors… 
Highly Cited
2006
Highly Cited
2006
The purpose of this study is to investigate the role of carbonic anhydrase IX (CAIX) expression in predicting the response to… 
Highly Cited
2005
Highly Cited
2005
Purpose: Renal cancer response to interleukin 2 (IL-2) therapy and patient survival has been correlated with tumor histology and… 
Highly Cited
2004
Highly Cited
2004
PURPOSE The natural history of renal cell carcinoma (RCC) is complex and not entirely explained by conventional prognostic…