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CAIX Inhibitor DTP348

Known as: 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide, DTP348 
An orally bioavailable, nitroimidazole-based sulfamide, carbonic anhydrase IX (CAIX) inhibitor with potential antineoplastic activity. Upon… Expand
National Institutes of Health

Papers overview

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2018
2018
Abstract Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has… Expand
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2015
2015
Triple negative, resistant or metastatic disease are major factors in breast cancer mortality, warranting novel approaches… Expand
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2015
2015
AIMS To test the hypothesis that the hypoxia marker carbonic anhydrase IX (CAIX), and the cholangiocytic/progenitor markers… Expand
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2013
2013
surgery. The individual response to TACE is mostly unpredictable, and to date, only the tumor diameter has been suggested as a… Expand
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2013
2013
To survive in various environments, from host tissue to soil, opportunistic bacterial pathogens must be metabolically flexible… Expand
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2011
2011
PurposeAs hypoxia is believed to play an important role in the development and progression of prostate cancer, we evaluated… Expand
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2010
2010
Carbonic anhydrase IX (CAIX, gene G250/MN-encoded transmembrane protein) is highly expressed in various human epithelial tumors… Expand
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2006
2006
The purpose of this study is to investigate the role of carbonic anhydrase IX (CAIX) expression in predicting the response to… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE Renal cancer response to interleukin 2 (IL-2) therapy and patient survival has been correlated with tumor histology and… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE The natural history of renal cell carcinoma (RCC) is complex and not entirely explained by conventional prognostic… Expand
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