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C-Circle

Known as: C-Circles, Extrachromosomal Telomeric C-Rich DNA Circles, CC 
A stretch of telomeric DNA where the normally guanine-rich (TTAGGG)n overhanging sequence has gaps while the cytosine-rich (AATCCC)n opposite strand… 
National Institutes of Health

Related topics

Related topics

1 relation
Chromosomes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner
Cancers must maintain their telomeres at lengths sufficient for cell survival. In several cancer subtypes, a recombination-like… 
2018
2018
Abstract B14: Establishment and characterization of in vitro models of alternative lengthening of telomeres (ALT) in pediatric high-grade glioma
Telomeres consist of many kilobases of repeated TTAGGG sequences at the ends of chromosomes, protected by a sequence-specific… 
Review
2017
Review
2017
Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms
Cancer cells require telomere maintenance to enable uncontrolled growth. Most often telomerase is activated, although a subset of… 
2017
2017
Abstract 3466: ALT-positive pediatric high grade glioma cells display chemosensitivity to ATR pathway inhibition
Overcoming the end-replication problem is a major hurdle for cancer cells due to progressive telomere shortening that results… 
2015
2015
What's that smile worth? Social reward influences spatial orienting.
A wealth of recent research indicates that rewarded singletons capture attention. However, it is unclear whether reward may also… 
2015
2015
Abstract B14: ALT specific C-circle detection in a whole blood of cancer patients using qPCR assay
The goal of this study was to evaluate a real-time qPCR assay, which can be used in clinical research environments for detection… 
2015
2015
Clinical and biological studies of the Alternative Lengthening of Telomeres in paediatric brain tumours
Certain cancers maintain telomeres using the alternative lengthening of telomeres (ALT), which is associated with mutations to… 
Review
2013
Review
2013
Telomere Maintenance Mechanisms: Prognostic and Therapeutic Implications for the Pathologist and Oncologist
In neoplasia, telomere maintenance mechanisms (TMMs) can be prognostic and may direct therapy in the future. Two types of TMM… 
2013
2013
Hybrid local search polynomial-expanded linear multiuser detector for DS/CDMA systems
This work proposes a new multiuser detector for DS/CDMA systems constituted by the polynomial Minimum Mean-Squared Error MMSE… 
2007
2007
Research on theEvolution ModelfortheVirtual Organization ofCooperative Information Storage
Inthecurrent network applications, the user-based cooperative information storage, working asa virtual organization, hasalready… 
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