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C(alpha)-formylglycine

Known as: 3-oxoalanine, (2S)-2-amino-3-oxopropanoic acid, L-alpha-formylglycine 
National Institutes of Health

Related topics

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3 relations

Broader (2)

AlanineGlycine
analogs & derivatives

Papers overview

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Highly Cited
2010
Highly Cited
2010
Anaerobic sulfatase‐maturating enzyme – A mechanistic link with glycyl radical‐activating enzymes?
Sulfatases form a major group of enzymes present in prokaryotes and eukaryotes. This class of hydrolases is unique in requiring… 
2009
2009
Mechanistic investigations of anaerobic sulfatase-maturating enzyme: direct Cbeta H-atom abstraction catalyzed by a radical AdoMet enzyme.
Sulfatases are unique in requiring an essential post-translational modification of a critical active-site cysteinyl or seryl… 
2007
2007
First evidences for a third sulfatase maturation system in prokaryotes from E. coli aslB and ydeM deletion mutants
2003
2003
Identification of formylglycine in sulfatases by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
C(alpha)-Formylglycine, the catalytic amino acid residue in the active site of sulfatases, is generated by post-translational… 
Review
2003
Review
2003
A Major Step on the Road to Understanding a Unique Posttranslational Modification and Its Role in a Genetic Disease
Highly Cited
2001
Highly Cited
2001
Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.
Arylsulfatase A (ASA) belongs to the sulfatase family whose members carry a C(alpha)-formylglycine that is post-translationally… 
2001
2001
Characterization of Posttranslational Formylglycine Formation by Luminal Components of the Endoplasmic Reticulum*
Cα-formylglycine is the key catalytic residue in the active site of sulfatases. In eukaryotes formylglycine is generated during… 
Review
1998
Review
1998
A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease
In multiple sulfatase deficiency, a rare human lysosomal storage disorder, all known sulfatases are synthesized as catalytically… 
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