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Brontictuzumab

Known as: Immunoglobulin G2-lambda, Anti-(homo Sapiens Notch1 (Notch 1, Translocation-associated Notch-1, TAN-1,Tan1)), Humanized Monoclonal Antibody 
A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, brontictuzumab… 
National Institutes of Health

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OMP-52M51
antigen binding

Papers overview

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2017
2017
Pancreatic islet regeneration through PDX-1/Notch-1/Ngn3 signaling after gastric bypass surgery in db/db mice
In view of the compelling anti-diabetic effects of gastric bypass surgery (GBS) in the treatment of morbid obesity, it is… 
2015
2015
Abstract C42: Safety and preliminary efficacy results of a first-in-human phase I study of the novel cancer stem cell (CSC) targeting antibody brontictuzumab (OMP-52M51, anti-Notch1) administered…
Background: The Notch pathway plays a key role in embryonic development, the regulation of stem and progenitor cells, and is… 
2015
2015
Notch-1 下调对双氢青蒿素抗人骨肉瘤细胞株U-2OS存活率的影响
2014
2014
Notch-1 and Ki-67 receptor as predictors for the recurrence and prognosis of Kimura's disease.
Kimura's disease (KD) is a rare chronic disease with unknown origin. It remains controversial in KD's diagnosis, treatment… 
2007
2007
Notch-1 Immunoexpression in Human and Mouse Cornea
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