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Bcl-2 Homology Domain

Proteins that are related to bcl-2 are characterized by the presence of one or more highly conserved stretches of homology with bcl-2, designated BH1… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma
The functional significance of neuronal death for pathogenesis of epilepsy and the underlying molecular mechanisms thereof remain… 
2010
2010
Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus
Prolonged seizures (status epilepticus) are associated with brain region-specific regulation of apoptosis-associated signaling… 
2009
2009
The role of Bcl-2 homology domain (BH) 3-only proteins in stress-induced cell death of mouse neocortical neurons associated with ischemic brain injury
2007
2007
Full Length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons
BackgroundBcl-2 homology domain (BH) 3-only proteins are pro-apoptotic proteins of the Bcl-2 family that couple stress signals to… 
2007
2007
Real-time single cell analysis of Bid cleavage and translocation in cisplatin-induced apoptosis
Cancer cell apoptosis can be induced by cisplatin, an efficient anticancer agent. However, its mechanism is not fully understood… 
Highly Cited
2006
Highly Cited
2006
Real Time Single Cell Analysis of Bid Cleavage and Bid Translocation during Caspase-dependent and Neuronal Caspase-independent Apoptosis*
Bcl-2 homology domain (BH) 3-only proteins couple stress signals to evolutionarily conserved mitochondrial apoptotic pathways… 
Highly Cited
2005
Highly Cited
2005
Phagocytosis-Induced Apoptosis in Macrophages Is Mediated by Up-Regulation and Activation of the Bcl-2 Homology Domain 3-Only Protein Bim1
Cell death by apoptosis is important in immune cell homeostasis and in the defense against infectious microorganisms. The… 
2004
2004
Erratum: Critical Role for DP5/Harakiri, a Bcl-2 Homology Domain 3-Only Bcl-2 Family Member, in Axotomy-Induced Neuronal Cell Death (Journal of Neuroscience (April 14, 2004) (3721-3725))
Highly Cited
2003
Highly Cited
2003
Gene expression during ER stress–induced apoptosis in neurons
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of ischemic and neurodegenerative disorders. Treatment… 
Highly Cited
2000
Highly Cited
2000
Exon Skipping in Mcl-1 Results in a Bcl-2 Homology Domain 3 Only Gene Product That Promotes Cell Death*
Mcl-1 is a member of the Bcl-2 family that is regulated transcriptionally and post-transcriptionally, with expression of the full… 
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