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BRAF NP_004324.2:p.V600K

Known as: Serine/Threonine-Protein Kinase B-raf Val600Lys, NP_004324.2:p.Val600Lys, BRAF p.Val600Lys 
A change in the amino acid residue at position 600 in the serine/threonine protein kinase B-raf protein where valine has been replaced by lysine.
National Institutes of Health

Papers overview

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2017
2017
Clinical and therapeutic implications of BRAF mutation heterogeneity in metastatic melanoma
Heterogeneity of BRAF mutation in melanoma has been a controversial subject. Quantitative data on BRAF allele frequency (AF) are… 
2017
2017
Distinct gene expression, mutational profile and clinical outcomes of V600E and V600K/R BRAF-mutant metastatic melanoma (MM).
9541Background: BRAF V600E and V600K/R mm have distinct clinicopathologic features suggesting different etiology. V600K/R mm… 
2017
2017
Zielgerichtete Therapie bei BRAF-Mutation
Die Einführung der BRAF-Inhibitoren hat die Therapiemöglichkeiten beim nicht resezierbaren beziehungsweise metastasierten… 
2017
2017
COX-2 expression positively correlates with PD-L1 expression in human melanoma cells
The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have prompted investigators to implement novel clinical… 
Highly Cited
2014
Highly Cited
2014
Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF…
The approval of vemurafenib in the US 2011 and in Europe 2012 improved the therapy of not resectable or metastatic melanoma… 
2014
2014
Melanoma: Blocking BRAF to the BRIM
In the past few years, the treatment of melanoma has been revolutionised by the approval of the CTLA-4 antibody, ipilimumab, and… 
2012
2012
Clinicopathologic Features of V600E and V600K Melanoma—Letter
The presence of a BRAF mutation in a melanoma tumor predicts response to BRAF inhibitors; however, the biological characteristics… 
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