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BPR0L075

National Institutes of Health

Papers overview

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2013
2013
Paclitaxel plays a major role in the treatment of ovarian cancer; however, resistance to paclitaxel is frequently observed. Thus… Expand
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2012
2012
BPR0L075, 6-methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole, is a tubulin-binding agent that inhibits tubulin polymerization by… Expand
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2012
2012
BPR0L075 [6-methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole] is a novel anti-microtubule drug with anti-tumor and anti… Expand
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Highly Cited
2011
Highly Cited
2011
Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug candidate for BPR0L075 (1), an indole-based… Expand
Highly Cited
2010
Highly Cited
2010
Background Anti-mitotic compounds (microtubule de-stabilizers) such as vincristine and vinblastine have been shown clinically… Expand
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2010
2010
BACKGROUND Antimitotic tubulin-binding BPR0L075 is structurally analogous to the vascular-disrupting combretastatin A-4… Expand
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Highly Cited
2009
Highly Cited
2009
BPR0L075 (2) is a potential anticancer drug candidate designed from Combretastatin A-4 (1) based on the bioisosterism principle… Expand
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2008
2008
6-Methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075) (1) is a potent inhibitor of tubulin polymerization which exhibits… Expand
2006
2006
The concise synthesis and structure–activity relationship (SAR) studies of 3‐aroylindoles were carried out in an effort to… Expand
Highly Cited
2004
Highly Cited
2004
  • Ching-Chuan Kuo, H. Hsieh, +7 authors Jang-Yang Chang
  • Cancer Research
  • 2004
  • Corpus ID: 14270604
BPR0L075 is a novel synthetic compound discovered through research to identify new microtubule inhibitors. BPR0L075 inhibits… Expand
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