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BO 653

Known as: BO-653 
National Institutes of Health

Papers overview

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2010
2010
Design, synthesis, and action of antiatherogenic antioxidants.
Ample evidence supports the critical role of oxidized low-density lipoprotein (ox-LDL) in initiation and progression of… 
2008
2008
Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation.
2007
2007
Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.
2006
2006
Chemical structure–dependent gene expression of proteasome subunits via regulation of the antioxidant response element
Antioxidants possess potent ability to regulate gene expression beyond their specific antioxidant activity. Genomic analysis… 
Review
2003
Review
2003
BO-653. Chugai.
BO-653 is an antioxidant under development by Chugai for the potential treatment of atherosclerosis and the prevention of… 
2003
2003
Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.
Antioxidants have been considered as potential antiatherogenic agents by inhibiting oxidation of low-density lipoprotein (LDL… 
2002
2002
Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits.
2002
2002
Antioxidant Action of 2,2,4,6-Tetra-Substituted 2,3-Dihydro-5-hydroxybenzofuran Against Lipid Peroxidation: Effects of Substituents and Side Chain
With increasing evidence suggesting the involvement of oxidative stress in various disorders and diseases, the role of… 
2000
2000
Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.
2, 3-Dihydro-5-hydroxy-2, 2-dipentyl-4, 6-di-tert-butylbenzofuran (BO-653) and probucol, which act as radical scavenging… 
1999
1999
Antioxidant BO-653 and human macrophage-mediated LDL oxidation.
Oxidation of LDL is now widely accepted to be involved in atherogenesis. The aim of this study was to examine the effect of BO… 
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