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BNC 105

Known as: BNC-105, BNC105 
National Institutes of Health

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2 relations

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AnisolesBenzofurans

Papers overview

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2016
2016
Abstract 4982: BNC105 induces tumor micro-environment changes which enhance the efficacy of checkpoint inhibitor therapy in preclinical models
BNC105 is a Phase II stage drug that specifically targets tubulin causing rapid depolymerisation. The therapeutic window of… 
2015
2015
Abstract 1551: Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesothelioma, ovarian and…
BNC105 is a tubulin depolymerisation agent. Its activity includes effects on both cancer cells and on solid tumor… 
2013
2013
Abstract 4039: Harnessing the tumor adaptive response to hypoxia to identify novel combinations of the vascular disrupting agent BNC105 with targeted therapeutics.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC BNC105 is a small molecule Vascular Disrupting Agent… 
2013
2013
Abstract B67: Induction of tumor hypoxia synergises with inhibitors of tumor metabolic and angiogenic adaptive responses to suppress tumor growth and enhance host survival.
BNC105 is a compound that exerts an anti-cancer action through selective destruction of tumor blood vessels. A single IV dose of… 
2011
2011
Discovery and clinical development of BNC105, a tubulin targeting small molecule that selectively disrupts the vasculature in solid tumours
2011
2011
Functional and molecular biomarker analysis demonstrates pharmacological activity for the novel vascular disrupting agent BNC105 in a first in human clinical study
2010
2010
Abstract 2498: BNC105 is a tubulin polymerization inhibitor that exhibits vascular disruptive activity in renal cancer and causes upregulation in HIF1alpha, HIF2alpha and mTOR
BNC105 is a tubulin polymerization inhibitor. This agent selectively disrupts the vasculature in tumors, and in addition acts as… 
2010
2010
Molecular Cancer Therapeutics BNC 105 : A Novel Tubulin Polymerization Inhibitor That Selectively Disrupts Tumor Vasculature and Displays Single-Agent Antitumor Efficacy
Dow Vascular disruption agents (VDA) cause occlusion of tumor vasculature, resulting in hypoxia-driven tumor cell necrosis. Tumor… 
2009
2009
Abstract #5564: BNC105 is a tubulin targeting agent that is not susceptible to efflux by Pgp transporter expression, and yields additive therapeutic benefit when combined with other anti-cancer…
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO BNC105 is a novel tubulin targeting agent that exhibits very high anti-tumor… 
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