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BMS 193885

Known as: BMS-193885, BMS193885 
 
National Institutes of Health

Related topics

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2 relations

Broader (2)

DihydropyridinesPhenylurea Compounds

Papers overview

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2019
2019
Radiosynthesis and in vivo evaluation of 11C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors
BackgroundNeuropeptide Y (NPY) has been implicated in a wide variety of physiological processes, including feeding, learning… Expand
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2018
2018
Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake… Expand
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2018
2018
Orexin-A signaling in the paraventricular nucleus modulates spontaneous firing of glucose-sensitive neurons and promotes food intake via the NPY pathway in rats.
Understanding the mechanisms regulating feeding is crucial to unraveling the pathogenesis of obesity. The study primary explored… Expand
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2008
2008
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist.
Treatment of obesity is still a large unmet medical need. Neuropeptide Y is the most potent orexigenic peptide in the animal… Expand
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2004
2004
Dihydropyridine neuropeptide Y Y1 receptor antagonists 2. bioisosteric urea replacements.
Structure-activity studies around the urea linkage in BMS-193885 (4a) identified the cyanoguanidine moiety as an effective urea… Expand
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