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BMI1 Inhibitor PTC596

Known as: PTC596, Polycomb Ring Finger Oncogene Inhibitor PTC596 
An orally active inhibitor of the polycomb ring finger oncogene BMI1 (B-cell-specific Moloney murine leukemia virus integration site 1), with… 
National Institutes of Health

Related topics

Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

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Review
2019
Review
2019
The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma
Introduction: A novel tubulin binding agent PTC596, which is currently in clinical trials for solid tumors, was originally… 
2019
2019
S122 THE FIRST-IN-CLASS, ORALLY AVAILABLE BMI-1 MODULATORS PTC-028 AND PTC596 DISPLAY POTENT ACTIVITY IN PRE-CLINICAL MODELS OF MULTIPLE MYELOMA
2019
2019
The first-in-class BMI-1 modulators PTC-028 and PTC596 display potent activity in pre-clinical models of multiple myeloma
2018
2018
Preclinical studies of BMI-1 modulator PTC596 in diffuse intrinsic pontine gliomas, pediatric high-grade gliomas and medulloblastoma.
e14051Background: Diffuse intrinsic pontine glioma (DIPG) is a universally fatal brainstem tumor with survival < 1 year despite… 
2018
2018
DIPG-13. SENSITIVITY OF DIPG CELLS TO BMI-1 MODULATOR PTC596 IS INDEPENDENT OF EZH2 ACTIVITY
2018
2018
Abstract 5864: Novel anti-BMI-1 therapy in non-small cell lung cancer
Lung cancer represents one of the most significant and lethal diseases worldwide. Advances in treatment protocols, the… 
2016
2016
Phase 1 results of PTC596, a novel small molecule targeting cancer stem cells (CSCs) by reducing levels of BMI1 protein
2012
2012
511 Identification of a Small Molecule (PTC596) That Preferentially Depletes Tumor Stem Cells by Reducing Levels of Functional BMI1 Protein
2011
2011
ポリコーム群遺伝子 Bmi1 による造血幹細胞の運命決定制御
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