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A newly synthesized cyclic hydroxamic acid compound, BMD188 [cis-l-hydroxy-4-(l-naphthyl)-6-oc-tylpiperidine-2-one], was found to… Expand We recently developed a class of novel anti-prostate cancer compounds, cyclic hydroxamates that elicit a potent apoptotic… Expand BACKGROUND
Prostate cancer is the most frequently diagnosed malignancy in the Western countries. Apoptosis-targeted drug… Expand BACKGROUND
In the preceding paper, we demonstrated that, BMD188 [cis-1-hydroxy-4-(1-naphthyl)-6-octylpiperidine-2-one], a newly… Expand Cytochrome c release from mitochondria to and subsequent accumulation in the cytosol has been considered a prerequisite for… Expand