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BM-1197

 
National Institutes of Health

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Aniline CompoundsSulfonamides

Papers overview

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2019
2019
A novel Bcl-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway
Bcl-2 family members play an important role in the development of malignant lymphoma and can induce drug resistance in anticancer… Expand
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2015
2015
First MCL-1-selective BH3 mimetics as potential therapeutics for targeted treatment of cancer
First MCL-1-selective BH3 mimetics as potential therapeutics for targeted treatment of cancer 
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2015
2015
BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma.
OBJECTIVES To evaluate the anti-tumor effect of BM-1197, a new potent and highly specific small molecule inhibitor of Bcl-2/Bcl… Expand
Highly Cited
2014
Highly Cited
2014
BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo
Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological… Expand
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2014
2014
The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells
Small molecule BH3 mimetics comprise a promising new chemotherapeutic strategy for treating relapsed or chemoresistant cancer. In… Expand
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2012
2012
412 Antitumor Activity of BM-1197, a Dual Inhibitor of Bcl-2 and Bcl-xL, in Small Cell Lung Cancer Tumors
 
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