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BIT225

National Institutes of Health

Papers overview

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2016
2016
The antiviral compound BIT225 inhibits HIV-1 replication in myeloid dendritic cells.
BACKGROUND Previous studies with BIT225 (N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide) have demonstrated a unique… 
2016
2016
A Phase 1 b / 2 a study of the safety , pharmacokinetics and antiviral activity of BIT 225 in patients with HIV-1 infection
Objectives: BIT225 (N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide), a novel acyl-guanidine, is a novel antiviral… 
2014
2014
Docking assay of small molecule antivirals to p7 of HCV
2013
2013
Computational modeling of the p7 monomer from HCV and its interaction with small molecule drugs
Hepatitis C virus p7 protein is a 63 amino acid polytopic protein with two transmembrane domains (TMDs) and one of the prime… 
2013
2013
1208 BIT225, AN HCV-P7 INHIBITOR, WITH ENHANCED ANTI-HCV ACTIVITY IN COMBINATION WITH PEGYLATED INTERFERONalfa- 2b AND RIBAVIRIN IN HCV GENOTYPE-1 TREATMENT NAÏVE SUBJECTS: PHARMACOKINETIC AND…
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