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BIT225

 
National Institutes of Health

Papers overview

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2018
2018
P7 is the only viral channel encoded by the Hepatitis C Virus (HCV) genome. It is a small, highly hydrophobic protein containing… Expand
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2016
2016
OBJECTIVES BIT225 (N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide), a novel acyl-guanidine, is a novel antiviral drug… Expand
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2016
2016
BackgroundPrevious studies with BIT225 (N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide) have demonstrated a unique… Expand
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2015
2015
BACKGROUND The current standard care therapy for hepatitis C virus (HCV) infection consists of two regimes, namely interferon… Expand
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2014
2014
Protein p7 of HCV is a 63 amino acid channel forming membrane protein essential for the progression of viral infection. With this… Expand
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2013
2013
Hepatitis C virus p7 protein is a 63 amino acid polytopic protein with two transmembrane domains (TMDs) and one of the prime… Expand
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Review
2012
Review
2012
Acylguanidines are a new class of antiviral compounds with the unique ability to target both RNA polymerase and transmembrane… Expand
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2011
2011
Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell… Expand
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2010
2010
Building on previous findings that amiloride analogues inhibit HIV-1 replication in monocyte-derived macrophages (MDM), Biotron… Expand
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2010
2010
The novel small molecule, BIT225 (N-[5-(1-methyl-1H-pyrazol-4-yl)-napthalene-2-carbonyl]-guanidine: CAS No. 917909-71-8), was… Expand
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