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BIBW 2992

Known as: BIBW-2992, BIBW2992 
National Institutes of Health

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Afatinib

Papers overview

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2016
2016
Use of BIBW 2992, a novel irreversible EGFR/HER2 tyrosine kinase inhibitor (TKI), to treat patients with HER2-positive metastatic breast cancer after failure of treatment with trastuzumab.
1023 Background: BIBW 2992 (Tovok) is an oral, novel, and potent, irreversible dual epidermal growth factor receptor (EGFR) and… 
2011
2011
Feasibility of combining EGFR- and VEGF(R)-targeted agents in colorectal cancer.
443 Background: The extensive cross-talk between EGFR and VEGF(R) argues for joint targeting of the two signaling pathways… 
2010
2010
BIBW 2992 versus cetuximab in patients with metastatic or recurrent head and neck cancer (SCCHN) after failure of platinum-containing therapy with a cross-over period for progressing patients…
5501 Background: BIBW 2992 is a novel, potent, orally bioavailable irreversible inhibitor of EGFR/HER1 and HER2 receptor tyrosine… 
2010
2010
Addition of BIBW 2992, an irreversible inhibitor of EGFR/HER1 and HER2, to letrozole in estrogen receptor (ER)-positive metastatic breast cancer (mBC) progressing on letrozole monotherapy.
1072 Background: Inhibition of HER1/2 signaling via possible cross-talk between the ER and HER1/2 signaling pathways restores… 
2009
2009
A phase II study of BIBW 2992, a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor (TKI), in patients with adenocarcinoma of the lung and activating EGFR mutations after failure of one…
8013 Background: EGFR mutations are associated with exquisite sensitivity to EGFR TKIs in NSCLC. A phase II trial evaluating the… 
2008
2008
Use of BIBW 2992, a novel irreversible EGFR/HER2 TKI, to induce regression in patients with adenocarcinoma of the lung and activating EGFR mutations: Preliminary results of a single-arm phase II…
8026 Background: BIBW 2992 is a highly potent dual EGFR and HER2 inhibitor with preclinical activity in cell lines harboring EGFR… 
2008
2008
A phase II trial of weekly alternating sequential administration of BIBF1120 and BIBW2992 in patients with advanced colorectal cancer
15001 Background: BIBF1120 is a triple angiokinase inhibitor (VEGFR1–3, PDGFR and FGFR). BIBW2992 is an inhibitor of EGFR and… 
2006
2006
A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a 3 week on 1 week off schedule in patients with advanced solid tumors.
3091 Background: BIBW 2992 is a highly potent irreversible dual EGFR /HER2 receptor tyrosine kinase inhibitor. This is the first… 
2006
2006
573 POSTER Phase I study of BIBW2992, an oral irreversible dual EGFR/HER2 inhibitor, showing activity in tumors with mutated EGFR
2006
2006
567 POSTER Efficacy of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in combination with cytotoxic agents
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