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BI-847325

Known as: BI 847325, MEK/Aurora Kinase Inhibitor BI 847325 
An orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon… 
National Institutes of Health

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Aniline CompoundsIndoles

Papers overview

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2015
2015
Abstract 703: A novel ATP-competitive MEK/Aurora kinase inhibitor BI-847325 reverses acquired BRAF inhibitor resistance through suppression of Mcl-1 and inhibition of MEK expression
BACKGROUND: BRAF/MEK inhibitors have shown promising levels of response in melanomas harboring the BRAF V600E mutation, however… 
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