BI-847325

Known as: BI 847325, MEK/Aurora Kinase Inhibitor BI 847325 
An orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon… (More)
National Institutes of Health

Papers overview

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2016
2016
Although the MAPK pathway is frequently deregulated in cancer, inhibitors targeting RAF or MEK have so far shown clinical… (More)
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2015
2015
Resistance to BRAF inhibitors is a major clinical problem. Here, we evaluate BI-847325, an ATP-competitive inhibitor of MEK and… (More)
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2015
2015
This study determined the safety, maximum tolerated dose (MTD), pharmacokinetics, and preliminary efficacy of BI 847325, an oral… (More)
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