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Type 1 vs type 2 calreticulin mutations in primary myelofibrosis: differences in phenotype and prognostic impact
ABSTRACT DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear… Expand Tumor hypoxia has been reported to cause a functional loss in DNA mismatch repair (MMR) system as a result of downregulation of… Expand Many organisms use circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila, the master… Expand Notch signaling pathway maintains stem cells through transcriptional activation of HES/HEY family members to repress tissue… Expand Circadian control depends on oscillating transcription factors, master switches synchronized by stimuli such as light and feeding… Expand An autofeedback loop associated with transcription of clock gene(s), Per(s), is generally accepted as the molecular machinery of… Expand Human DEC (differentiallyexpressed in chondrocytes), mouse STRA (stimulated with retinoic acid), and rat SHARP (split and… Expand The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four… Expand Adaptation to hypoxia is a crucial process both physiologically (i.e. in chondrocytes) and pathologically (i.e. in tumor cells… Expand