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BET Inhibitor

Known as: BET Bromodomain Inhibitor 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
BET inhibition therapy counteracts cancer cell survival, clonogenic potential and radioresistance mechanisms in rhabdomyosarcoma cells.
2020
2020
The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma.
2020
2020
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
Primary and acquired drug resistance imposes a major threat to achieving optimized clinical outcomes during cancer treatment… 
2019
2019
Co-inhibition of BET proteins and PD-L1 as a potential therapy for OSCC through synergistic inhibition of FOXM1 and PD-L1 expressions.
BACKGROUND Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators that facilitate the… 
2018
2018
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Highly Cited
2017
Highly Cited
2017
The suppression of bromodomain and extra‐terminal domain inhibits vascular inflammation by blocking NF‐κB and MAPK activation
There is increasing evidence indicating that bromodomain and extra‐terminal domain (BET) proteins play a critical role in the… 
2017
2017
BET bromodomain inhibitor JQ1 decreases CD30 and CCR4 expression and proliferation of cutaneous T-cell lymphoma cell lines
Bromodomain and external domain (BET) proteins regulate cell growth, proliferation, cell cycle, and differentiation in various… 
Review
2016
Review
2016
Small-Molecule Targeting of BET Proteins in Cancer.
2016
2016
Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
Highly Cited
2015
Highly Cited
2015
Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma
Pathologic c-Myc expression is frequently detected in human cancers, including Merkel cell carcinoma (MCC), an aggressive skin… 
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