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Endothelin-1 (ET-1), a peptide produced by the vascular endothelium, causes profound renal vasoconstriction by binding to… Expand Wound contraction is an important event that minimizes the wound defect during the healing process. Involvement of insulin-like… Expand BACKGROUND
Prior studies suggest an important role for coronary endothelium in ischemia/reperfusion (I/R) injury. Decreased… Expand 1 Endothelin‐1 (ET‐1; 3–10 nm) raised the tone of rat bladders bathed in buffer containing atropine (1 μm) plus guanethidine (3.4… Expand Summary: The novel endothelin (ET) receptor antagonists BE‐18257A and BE‐18257B were isolated from the fermentation products of… Expand Computer‐aided molecular modelling of the endothelin (ET‐A) receptor antagonists, BQ‐123 and BE‐18257B. shows that they have very… Expand Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized 125I-ET-1 binding to a porcine aortic smooth… Expand A competitive endothelin (ET) antagonist, BE-18257B, was isolated from the fermentation products of Streptomyces misakiensis. It… Expand The structures of novel endothelin-binding inhibitors, BE-18257A and BE-18257B, were elucidated by spectral analyses and chemical… Expand