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BBI608

Known as: BB608, BBI-608 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Purpose: Napabucasin (2-acetylfuro-1,4-naphthoquinone or BBI-608) is a small molecule currently being clinically evaluated in… Expand
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2018
2018
Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide. While partial or complete tumor… Expand
2018
2018
STAT3 plays a vital role in maintaining the self-renewal of tumor stem cells. BBI608, a small molecule identified by its ability… Expand
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2017
2017
TPS3619Background: Cancer stem cells are considered to be fundamentally important for resistance to therapy, recurrence and… Expand
Review
2017
Review
2017
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… Expand
2017
2017
3529Background: Cancer stem cells are considered to be fundamentally important for resistance, recurrence and metastasis… Expand
2017
2017
4106Background: Cancer stem cells are fundamentally important for resistance to therapy, recurrence and metastasis. Napabucasin… Expand
Highly Cited
2015
Highly Cited
2015
  • Y. Li, H. Rogoff, +7 authors C. Li
  • Proceedings of the National Academy of Sciences
  • 2015
  • Corpus ID: 2021183
Significance Current cancer treatments ultimately fail owing to metastasis and relapse. The discovery of therapeutic approaches… Expand
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2015
2015
TPS4139 Background: BBI608 is an orally-administered first-in-class cancer stemness inhibitor. By targeting Stat3, BBI608 blocks… Expand
2015
2015
4069 Background: BBI608, a first-in-class CSC inhibitor that works through inhibiting Stat3, has shown potent synergistic anti… Expand