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Atacicept

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Post Hoc Analysis of the Phase II/III APRIL‐SLE Study: Association Between Response to Atacicept and Serum Biomarkers Including BLyS and APRIL
To assess the relationship between treatment response, baseline biomarker levels, and atacicept exposure in patients with… 
Review
2014
Review
2014
The efficacy of novel B cell biologics as the future of SLE treatment: a review.
Highly Cited
2011
Highly Cited
2011
Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial.
OBJECTIVE To assess the efficacy, safety, and biologic activity of atacicept in tumor necrosis factor antagonist-naive patients… 
Highly Cited
2011
Highly Cited
2011
Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: results of a phase II, randomized, placebo-controlled, dose-finding trial.
OBJECTIVE To assess the efficacy, safety, and biologic activity of atacicept in patients with rheumatoid arthritis (RA) in whom… 
Review
2011
Review
2011
Humoral autoimmunity in multiple sclerosis
Highly Cited
2009
Highly Cited
2009
An Exploratory Dose-Escalating Study Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous Atacicept in Patients with Systemic Lupus Erythematosus
Atacicept, a recombinant fusion protein containing the extracellular, ligand-binding portion of the transmembrane activator and… 
Highly Cited
2009
Highly Cited
2009
Atacicept in relapsed/refractory multiple myeloma or active Waldenström's macroglobulinemia: a phase I study
Background:Advanced multiple myeloma (MM) and Waldenström's macroglobulinemia (WM) are incurable B-cell malignancies. This is the… 
Review
2009
Review
2009
Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis
Background: Recent data suggest a key role for B cells in the pathogenesis of many autoimmune diseases including rheumatoid… 
Highly Cited
2008
Highly Cited
2008
Pharmacokinetics and Biological Activity of Atacicept in Patients With Rheumatoid Arthritis
Atacicept is a recombinant fusion protein containing the extracellular ligand‐binding portion of the transmembrane activator and… 
Highly Cited
2007
Highly Cited
2007
Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteers
Objective Atacicept, a recombinant fusion protein, blocks the activity of BLyS (a B-lymphocyte stimulator) and APRIL (a… 
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