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Antimetabolite FF-10502
Known as:
FF-10502
, FF-10502-01
An antimetabolite with potential antineoplastic activity. Upon administration, FF-10502 is able to enter the nucleus where it inhibits DNA…
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National Institutes of Health
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2019
2019
Phase 1/2 trial of FF-10502-01, a pyrimidine antimetabolite, in patients with advanced cholangiocarcinoma and solid tumors.
F. Janku
,
Shiraj Sen
,
+16 authors
G. Falchook
Journal of Clinical Oncology
2019
Corpus ID: 190897524
3008 Background: FF10502 is a synthetic pyrimidine nucleoside similar to gemcitabine (gem) with a sulfur in the pentose ring…
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2018
2018
Abstract 326: A novel antimetabolite, FF-10502-01 exhibits potent antitumor activity via inhibition of both DNA replication and DNA damage repair in solid tumor cells
Kazunori Saeki
,
Rena Uematsu
,
+5 authors
Shinji Hagiwara
Molecular and Cellular Biology / Genetics
2018
Corpus ID: 81581900
Introduction FF10502-01 is a synthetic pyrimidine nucleoside analogue that is structurally similar to gemcitabine (GEM) with a…
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2017
2017
Abstract CT100: First-in-human phase 1 trial of pyrimidine anti-metabolite FF-10502-01 in patients with advanced cancer
G. Falchook
,
Lindsay Bramwell
,
+7 authors
F. Janku
2017
Corpus ID: 80387486
Background: FF10502-01 is a synthetic pyrimidine nucleoside analogue that is structurally similar to gemcitabine with a…
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2017
2017
Abstract 5112: Evaluation of FF-10502-01, a new pyrimidine nucleoside analogue, in pancreatic (PANC) patient-derived xenograft (PDX) models compared to gemcitabine and in combination with nab…
Takeaki Suzuki
,
L. Paradiso
,
+7 authors
S. Watanabe
2017
Corpus ID: 80209217
Introduction FF-10502-01 is a synthetic pyrimidine nucleoside analogue structurally similar to gem with a substitution of sulfur…
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2017
2017
Abstract 5127:In vitroandin vivoevaluation of FF-10502-01, a new pyrimidine nucleoside analogue
S. Mima
,
Hiroki Nishikawa
,
+6 authors
Y. Shimada
2017
Corpus ID: 56825042
Introduction:FF-10502-01 is a synthetic pyrimidine nucleoside analogue structurally similar to gemcitabine (gem) with a…
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