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Anti-prolactin Receptor Antibody LFA102

Known as: LFA102 
A neutralizing antibody against the prolactin receptor (PRLR) with potential antineoplastic activity. Upon administration, anti-prolactin receptor… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Prolactin receptor targeting in breast and prostate cancers: New insights into an old challenge.
In the era of precision medicine, the identification of new targets is a constant challenge to improve cancer therapy… Expand
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2016
2016
Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer
LESSONS LEARNED Despite evidence for a role for prolactin signaling in breast and prostate tumorigenesis, a prolactin receptor… Expand
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2016
2016
Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer
In this issue of The Oncologist, Agarwal et al. report negative results from a phase I trial of LFA102. Although “negative” in… Expand
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2013
2013
Neutralization of prolactin receptor function by monoclonal antibody LFA102, a novel potential therapeutic for the treatment of breast cancer.
Numerous lines of evidence suggest that the polypeptide hormone prolactin (PRL) may contribute to breast and prostate… Expand
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Review
2013
Review
2013
Molecular pathways: blockade of the PRLR signaling pathway as a novel antihormonal approach for the treatment of breast and prostate cancer.
The prolactin (PRL)-prolactin receptor (PRLR) signaling complex has been implicated in the pathology of breast and prostate… Expand
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2013
2013
Large Molecule Therapeutics Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA 102 , a Novel Potential Therapeutic for the Treatment of Breast Cancer
Numerous lines of evidence suggest that the polypeptide hormone prolactin (PRL)may contribute to breast and prostate… Expand
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Review
2012
Review
2012
TITLE: Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, A Novel Potential Therapeutic for the Treatment of Breast Cancer AUTHORS AND AFFILIATIONS:
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Numerous lines of… Expand
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2011
2011
Abstract DDT02-02: Preclinical development of LFA102, a highly potent and selective neutralizing antibody against the prolactin receptor
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL The prolactin receptor (PRLR) is a class I cytokine… Expand
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2011
2011
P3-17-09: Neutralizing the Prolactin Receptor with Therapeutic Antibody LFA102: A Novel Approach for the Treatment of Breast Cancer.
 
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