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Anti-interferon gamma Monoclonal Antibody NI-0501

Known as: Anti-IFN gamma Monoclonal Antibody NI-0501, Anti-IFNg mAb NI-0501, NI-0501 
A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration… Expand
National Institutes of Health

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1 relation
antigen binding

Papers overview

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Review
2017
Review
2017
How to Treat Involvement of the Central Nervous System in Hemophagocytic Lymphohistiocytosis?
Opinion statementCentral nervous system (CNS)-hemophagocytic lymphohistiocytosis (HLH) is not a disease in itself, but it is part… Expand
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2017
2017
IFNɣ Block, Treosulfan Conditioning and αβ T Cell Deplete PBSCT for XIAP-Deficient HLH
The outcomes of hematopoietic stem cell transplantation (HSCT) for refractory hemophagocytic lymphohistiocytosis (HLH) in X… Expand
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2016
2016
A NOVEL TARGETED APPROACH TO THE TREATMENT OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH) WITH NI-0501, AN ANTI-INTERFERON GAMMA MONOCLONAL ANTIBODY
 
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2016
2016
Anti-interferon gamma monoclonal antibody NI-0501: A new option to render allogeneic HSCT for HLH safer and more effective?
 
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2016
2016
First EU PRIME designations
The names of the first four drugs to receive PRIME (PRIority MEDicines) status were released in June by the European Medicines… Expand
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2016
2016
Stemcentrx bags $5.8 billion, even as Notch agent underwhelms
The names of the first four drugs to receive PRIME (PRIority MEDicines) status were released in June by the European Medicines… Expand
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2015
2015
A Novel Targeted Approach to the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) with an Anti-Interferon Gamma (IFNγ) Monoclonal Antibody (mAb), NI-0501: First Results from a Pilot Phase 2…
Introduction Primary HLH (pHLH) is a rare immune regulatory disorder invariably lethal if untreated. It is driven by pathologic… Expand
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2015
2015
Anti interferon-gamma (IFNγ) monoclonal antibody treatment in a patient carrying an NLRC4 mutation and severe hemophagocytic lymphohistiocytosis
Background A growing body of evidence, in animals and humans, suggest that IFNg plays a pathogenic role in primary HLH (pHLH) and… Expand
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