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Anti-interferon gamma Monoclonal Antibody NI-0501
Known as:
Anti-IFN gamma Monoclonal Antibody NI-0501
, Anti-IFNg mAb NI-0501
, NI-0501
A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration…
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National Institutes of Health
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Related topics
Related topics
1 relation
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.
F. Locatelli
,
M. Jordan
,
+17 authors
C. de Min
New England Journal of Medicine
2020
Corpus ID: 218533218
BACKGROUND Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized by immune dysregulation and…
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Review
2017
Review
2017
How to Treat Involvement of the Central Nervous System in Hemophagocytic Lymphohistiocytosis?
A. Horne
,
R. Wickström
,
+4 authors
G. Janka
Current Treatment Options in Neurology
2017
Corpus ID: 16217145
Opinion statementCentral nervous system (CNS)-hemophagocytic lymphohistiocytosis (HLH) is not a disease in itself, but it is part…
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2017
2017
IFNɣ Block, Treosulfan Conditioning and αβ T Cell Deplete PBSCT for XIAP-Deficient HLH
C. O’Rafferty
,
M. Velangi
,
Sarah Lawson
,
P. Hiwarkar
,
J. Motwani
Journal of Clinical Immunology
2017
Corpus ID: 254645249
2016
2016
A NOVEL TARGETED APPROACH TO THE TREATMENT OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH) WITH NI-0501, AN ANTI-INTERFERON GAMMA MONOCLONAL ANTIBODY
M. Jordan
2016
Corpus ID: 89718337
2016
2016
Anti-interferon gamma monoclonal antibody NI-0501: A new option to render allogeneic HSCT for HLH safer and more effective?
F. Locatelli
,
M. Jordan
,
+9 authors
C. D. Min
2016
Corpus ID: 58247136
2016
2016
First EU PRIME designations
E. Schaper
Nature Biotechnology
2016
Corpus ID: 205269806
The names of the first four drugs to receive PRIME (PRIority MEDicines) status were released in June by the European Medicines…
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Highly Cited
2015
Highly Cited
2015
A Novel Targeted Approach to the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) with an Anti-Interferon Gamma (IFNγ) Monoclonal Antibody (mAb), NI-0501: First Results from a Pilot Phase 2…
Franco Locatelli Prof
,
C. Allen
,
+4 authors
C. D. Min
2015
Corpus ID: 78951743
Introduction Primary HLH (pHLH) is a rare immune regulatory disorder invariably lethal if untreated. It is driven by pathologic…
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2015
2015
Anti interferon-gamma (IFNγ) monoclonal antibody treatment in a patient carrying an NLRC4 mutation and severe hemophagocytic lymphohistiocytosis
C. Bracaglia
,
A. Gatto
,
+5 authors
F. De Benedetti
Pediatric Rheumatology Online Journal
2015
Corpus ID: 33284722
Background A growing body of evidence, in animals and humans, suggest that IFNg plays a pathogenic role in primary HLH (pHLH) and…
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