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Anti-LGR5 Monoclonal Antibody BNC101

Known as: BNC-101, BNC101, ET-101 
A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity… 
National Institutes of Health

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Related topics

1 relation
antigen binding

Papers overview

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2017
2017
Abstract 4695: Targeting the LGR5 complex with BNC101 to improve checkpoint inhibitor therapy in colorectal cancer
LGR5 is a well characterised marker of intestinal stem cells found at the base of intestinal crypts and a receptor for R-spondins… 
2017
2017
Bionomics Presents Promising BNC 101 Data at American Association for Cancer Research Conference
LGR5 is a well characterised marker of intestinal stem cells found at the base of intestinal crypts and a receptor for Rspondins… 
2015
2015
Abstract 2315: The LGR5 monoclonal antibody BNC101 has anti-tumor and anti-cancer stem cell activity in pancreatic cancer
BNC101 is a humanized monoclonal antibody (mAb) targeting LGR5 that has successfully completed IND-enabling studies for upcoming… 
2015
2015
Abstract 2639: Preclinical evaluation and biomarker identification for the anti-LGR5 mAb BNC101 in K-Ras mutant CRC and other solid tumor indications
2014
2014
Abstract 3894: Targeting colorectal and pancreatic cancer stem cells with the LGR5 monoclonal antibody BNC101
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA BNC101 is a monoclonal antibody (mAb) targeting LGR5… 
2014
2014
366 Targeting colorectal and pancreatic cancer stem cells with the LGR5 monoclonal antibody BNC101
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