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Anti-HER3 Monoclonal Antibody LJM716

Known as: LJM716 
A human monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3) with potential antineoplastic activity. Anti… 
National Institutes of Health

Papers overview

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2019
2019
Objective To express, purify and identify the single-chain fragment variable (scFv) against human epidermal growth factor… 
2017
2017
Background: Amplification/overexpression of ERBB receptors and/or ligands has been associated with resistance to anti-HER2… 
2015
2015
Background: Breast cancers that overexpress the human epidermal growth factor receptor 2 (HER2+) are driven by HER2/HER3/PI3K… 
2015
2015
Background: HER3 is a member of the ErbB family of receptor tyrosine kinases that are involved in the pathogenesis of many… 
2014
2014
2517 Background: The HER3 receptor is important for maintenance of EGFR- and HER2-driven cancers and targeted therapy resistance… 
2014
2014
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: Esophageal cancer is the eighth most common… 
2014
2014
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA HER3 is a member of the ErbB family of receptor tyrosine… 
2013
2013
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: Head and neck squamous cell carcinoma… 
2013
2013
  • 2013
  • Corpus ID: 33925111
We examined the effects of LJM716, an HER3 (ERBB3) neutralizing antibody that inhibits ligand-induced and ligand-independent HER3… 
2013
2013
We hypothesized that complete inhibition of HER3 is required for the optimal action of HER2 or PI3K/Akt inhibitors against HER2…