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Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547

Known as: 1C1-mcMMAF 
An auristatin analogue immunoconjugate directed against Eph receptor A2 (EphA2)-positive cancer cells with potential antineoplastic activity. Anti… Expand
National Institutes of Health

Papers overview

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2019
2019
CD103 mediates T-cell infiltration and organ allograft rejection, and depletion of CD103-expressing cells is a promising… Expand
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2017
2017
The targeting of therapeutics specifically to diseased tissue is crucial for the development of successful cancer treatments. The… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND EphA2 is overexpressed in many types of human cancer but is absent or expressed at low levels in normal epithelial… Expand
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Highly Cited
2008
Highly Cited
2008
The EphA2 receptor tyrosine kinase is selectively expressed on the surface of many different human tumors. We have previously… Expand
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2007
2007
CD22 is a B-cell specific antigen expressed on both normal and malignant cells. It is internalized rapidly upon binding to its… Expand
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Highly Cited
2006
Highly Cited
2006
The chimeric anti-CD30 monoclonal antibody cAC10, linked to the antimitotic agents monomethyl auristatin E (MMAE) or F (MMAF… Expand
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2006
2006
1991 Antibody-drug conjugates (ADC) with linker systems that are highly stable in circulation provide an effective and efficient… Expand
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