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Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547
Known as:
1C1-mcMMAF
An auristatin analogue immunoconjugate directed against Eph receptor A2 (EphA2)-positive cancer cells with potential antineoplastic activity. Anti…
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National Institutes of Health
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MEDI-547
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
An anti-CD103 antibody-drug conjugate prolongs the survival of pancreatic islet allografts in mice
Da Xue
,
Pili Liu
,
Wangming Chen
,
Chi Zhang
,
Lei Zhang
Cell Death and Disease
2019
Corpus ID: 203592768
CD103 mediates T-cell infiltration and organ allograft rejection, and depletion of CD103-expressing cells is a promising…
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2017
2017
Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells and Mouse Models.
Kelly E. Burns
,
H. Hensley
,
M. Robinson
,
Damien Thévenin
Molecular Pharmaceutics
2017
Corpus ID: 46756092
The targeting of therapeutics specifically to diseased tissue is crucial for the development of successful cancer treatments. The…
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Highly Cited
2009
Highly Cited
2009
EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma.
Jeong-Won Lee
,
H. Han
,
+15 authors
A. Sood
Journal of the National Cancer Institute
2009
Corpus ID: 15395807
BACKGROUND EphA2 is overexpressed in many types of human cancer but is absent or expressed at low levels in normal epithelial…
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Highly Cited
2008
Highly Cited
2008
A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.
D. Jackson
,
J. Gooya
,
+14 authors
D. Tice
Cancer Research
2008
Corpus ID: 19309059
The EphA2 receptor tyrosine kinase is selectively expressed on the surface of many different human tumors. We have previously…
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2007
2007
Non-Clinical Pharmacology of Anti-CD22 Antibody Drug Conjugates.
D. Xie
,
Jakub Baudys
,
+16 authors
S. Prabhu
2007
Corpus ID: 78544741
CD22 is a B-cell specific antigen expressed on both normal and malignant cells. It is internalized rapidly upon binding to its…
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Highly Cited
2006
Highly Cited
2006
Lysosomal Trafficking and Cysteine Protease Metabolism Confer Target-specific Cytotoxicity by Peptide-linked Anti-CD30-Auristatin Conjugates*
M. Sutherland
,
R. Sanderson
,
+10 authors
A. Wahl
Journal of Biological Chemistry
2006
Corpus ID: 22837817
The chimeric anti-CD30 monoclonal antibody cAC10, linked to the antimitotic agents monomethyl auristatin E (MMAE) or F (MMAF…
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2006
2006
Enhanced in vivo drug-linker stability of an anti-CD70 auristatin immunoconjugate
R. Sanderson
,
S. Alley
,
+5 authors
P. Senter
2006
Corpus ID: 201970995
1991 Antibody-drug conjugates (ADC) with linker systems that are highly stable in circulation provide an effective and efficient…
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