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Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547

Known as: 1C1-mcMMAF 
An auristatin analogue immunoconjugate directed against Eph receptor A2 (EphA2)-positive cancer cells with potential antineoplastic activity. Anti… Expand
National Institutes of Health

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MEDI-547

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2019
2019
An anti-CD103 antibody-drug conjugate prolongs the survival of pancreatic islet allografts in mice
CD103 mediates T-cell infiltration and organ allograft rejection, and depletion of CD103-expressing cells is a promising… Expand
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2017
2017
Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells and Mouse Models.
The targeting of therapeutics specifically to diseased tissue is crucial for the development of successful cancer treatments. The… Expand
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Highly Cited
2009
Highly Cited
2009
EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma.
BACKGROUND EphA2 is overexpressed in many types of human cancer but is absent or expressed at low levels in normal epithelial… Expand
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Highly Cited
2008
Highly Cited
2008
A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.
The EphA2 receptor tyrosine kinase is selectively expressed on the surface of many different human tumors. We have previously… Expand
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2007
2007
Non-Clinical Pharmacology of Anti-CD22 Antibody Drug Conjugates.
CD22 is a B-cell specific antigen expressed on both normal and malignant cells. It is internalized rapidly upon binding to its… Expand
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Highly Cited
2006
Highly Cited
2006
Lysosomal Trafficking and Cysteine Protease Metabolism Confer Target-specific Cytotoxicity by Peptide-linked Anti-CD30-Auristatin Conjugates*
The chimeric anti-CD30 monoclonal antibody cAC10, linked to the antimitotic agents monomethyl auristatin E (MMAE) or F (MMAF… Expand
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2006
2006
Enhanced in vivo drug-linker stability of an anti-CD70 auristatin immunoconjugate
1991 Antibody-drug conjugates (ADC) with linker systems that are highly stable in circulation provide an effective and efficient… Expand
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