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Alkaline Ceramidase 1

Known as: ACER1, EC 3.5.1.23, N-Acylsphingosine Amidohydrolase 3 
Alkaline ceramidase 1 (264 aa, ~31 kDa) is encoded by the human ACER1 gene. This protein is involved in the catabolism of sphingolipid ceramides.
National Institutes of Health

Papers overview

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2019
2019
New fluorogenic ceramidase substrates derived from the N-acyl modification of our previously reported probes (RBM14) are reported… Expand
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2017
2017
Summary Ceramides and their metabolites are important for the homeostasis of the epidermis, but much remains unknown about the… Expand
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Review
2017
Review
2017
Over the past three decades, extensive research has been able to determine the biologic functions for the main bioactive… Expand
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2010
2010
Plasma sphingosine‐1‐phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte… Expand
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Review
2008
Review
2008
Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is phosphorylated to form sphingosine-1… Expand
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