Aggrecans

Known as: Cartilage-Specific Proteoglycan Core Proteins, Cartilage Specific Proteoglycan Core Proteins, Proteoglycan of cartilage 
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
010020019792018

Papers overview

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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Recent published studies have shown that cartilage from ADAMTS-5-knockout mice, but not ADAMTS-4- or ADAMTS-1-knockout… (More)
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Highly Cited
2005
Highly Cited
2005
Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease… (More)
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Highly Cited
2003
Highly Cited
2003
The matrix components responsible for cartilage mechanical properties, type II collagen and aggrecan, are degraded in… (More)
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Highly Cited
2002
Highly Cited
2002
The perineuronal net forms the extracellular matrix of many neurons in the CNS, surrounding neuron cell bodies and proximal… (More)
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Highly Cited
2002
Highly Cited
2002
Osteoarthritis is a degenerative joint disorder characterized by breakdown of articular cartilage. Degradation of aggrecan, which… (More)
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Highly Cited
2000
Highly Cited
2000
SOX9 is a transcription factor that plays a key role in chondrogenesis. Aggrecan is one of the major structural components in… (More)
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Highly Cited
2000
Highly Cited
2000
A disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) is an extracellular matrix-anchored… (More)
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Highly Cited
1999
Highly Cited
1999
Chondrogenesis in cartilage development and repair and cartilage degeneration in arthritis can be regulated by mechanical-load… (More)
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Highly Cited
1997
Highly Cited
1997
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage… (More)
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Highly Cited
1996
Highly Cited
1996
Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified enzyme aggrecanase, and at least… (More)
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