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Aggrecans

Known as: Cartilage-Specific Proteoglycan Core Proteins, Cartilage Specific Proteoglycan Core Proteins, Proteoglycan of cartilage 
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Recent published studies have shown that cartilage from ADAMTS-5-knockout mice, but not ADAMTS-4- or ADAMTS-1-knockout… Expand
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Highly Cited
2003
Highly Cited
2003
The matrix components responsible for cartilage mechanical properties, type II collagen and aggrecan, are degraded in… Expand
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Review
2002
Review
2002
ABSTRACTAggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of… Expand
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Highly Cited
2002
Highly Cited
2002
The perineuronal net forms the extracellular matrix of many neurons in the CNS, surrounding neuron cell bodies and proximal… Expand
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Highly Cited
2000
Highly Cited
2000
A disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) is an extracellular matrix-anchored… Expand
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Highly Cited
1998
Highly Cited
1998
In the adult human, mesenchymal stem cells (MSCs) resident in bone marrow retain the capacity to proliferate and differentiate… Expand
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Review
1998
Review
1998
Aggrecan, a large aggregating proteoglycan, is one of the major structural components of cartilage. Its core protein contains… Expand
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Highly Cited
1997
Highly Cited
1997
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage… Expand
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Highly Cited
1996
Highly Cited
1996
Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified enzyme aggrecanase, and at least… Expand
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Highly Cited
1996
Highly Cited
1996
Very little is known about the turnover of extracellular matrix in the human intervertebral disc. We measured concentrations of… Expand
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