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Aggrecans

Known as: Cartilage-Specific Proteoglycan Core Proteins, Cartilage Specific Proteoglycan Core Proteins, Proteoglycan of cartilage 
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with… 
National Institutes of Health

Related topics

Related topics

11 relations
Chondroitin SulfatesIn BloodProcess of secretionagonists

Broader (2)

GlycosaminoglycansProteoglycan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice.
OBJECTIVE To investigate the in vivo effect of an imbalance between metalloproteinases and their inhibitors, tissue inhibitors of… 
Highly Cited
2003
Highly Cited
2003
Rapid regulation of collagen but not metalloproteinase 1, 3, 13, 14 and tissue inhibitor of metalloproteinase 1, 2, 3 expression in response to mechanical loading of cartilage explants in vitro.
Highly Cited
2002
Highly Cited
2002
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.
The mechanisms of aggrecan degradation in adult human articular, adult bovine nasal and fetal bovine epiphyseal cartilage in… 
Highly Cited
2000
Highly Cited
2000
Osteogenic protein 1 stimulates cells-associated matrix assembly by normal human articular chondrocytes: up-regulation of hyaluronan synthase, CD44, and aggrecan.
OBJECTIVE To determine the effects of osteogenic protein 1 (OP-1) on hyaluronan (HA), CD44, and aggrecan biosynthesis as well as… 
Highly Cited
1996
Highly Cited
1996
Interaction of Cartilage Matrix Protein with Aggrecan
Cartilage matrix protein (CMP) is a trimeric protein present in many types of cartilage extracellular matrix. It has recently… 
Highly Cited
1995
Highly Cited
1995
Cell-mediated Catabolism of Aggrecan
A rat chondrosarcoma cell line and primary bovine chondrocytes have been used to study cell-mediated aggrecan catabolism… 
Review
1994
Review
1994
The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions.
Highly Cited
1994
Highly Cited
1994
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
Native and recombinant neutrophil collagenase (MMP-8) was shown to cleave at the E373-A374 'aggrecanase' site in the… 
Review
1994
Review
1994
Regulation of proteoglycan expression in fibrotic liver and cultured fat-storing cells.
Highly Cited
1992
Highly Cited
1992
Structural analysis of the linkage region oligosaccharides and unsaturated disaccharides from chondroitin sulfate using CarboPac PA1.
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