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Aggrecans

Known as: Cartilage-Specific Proteoglycan Core Proteins, Cartilage Specific Proteoglycan Core Proteins, Proteoglycan of cartilage 
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with… 
National Institutes of Health

Related topics

Related topics

11 relations
Chondroitin SulfatesIn BloodProcess of secretionagonists

Broader (2)

GlycosaminoglycansProteoglycan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Alteration of cartilage mechanical properties in absence of β1 integrins revealed by rheometry and FRAP analyses.
2006
2006
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
2006
2006
Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis.
2004
2004
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
Extracts of normal mature articular cartilage contain aggrecan molecules which bear the G1 domain (the N-terminal globular domain… 
2003
2003
Proteoglycans in chicken gastrocnemius tendons change with exercise.
Highly Cited
2000
Highly Cited
2000
Age-related Changes in Aggrecan Glycosylation Affect Cleavage by Aggrecanase*
Aggrecan degradation involves proteolytic cleavage of the core protein within the interglobular domain. Because aggrecan is… 
1997
1997
Analysis of proteoglycan messages in human articular cartilage by a competitive PCR technique.
Highly Cited
1995
Highly Cited
1995
Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring.
Aggrecan is an essential matrix constituent of the soft tissues of the joint, which include the articular and meniscal cartilages… 
Review
1994
Review
1994
Regulation of proteoglycan expression in fibrotic liver and cultured fat-storing cells.
1992
1992
Effect of insulin-like growth factor-I on the synthesis and distribution of link protein and hyaluronan in explant cultures of articular cartilage.
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