Aes-103
National Institutes of Health
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In preclinical and early phase pharmacologic trials in sickle cell disease, the percentage of sickled erythrocytes after…
Background: Under hypoxic conditions, sickle hemoglobin (HbS) polymerizes, causing morphologic distortion (sickling) of red blood…
Abstract Background Aes-103 (5-hydroxymethylfurfural, 5-HMF) is a putative anti-sickling agent that has undergone pre-clinical…
Abstract 3210 5-HMF (5-hydroxymethyl-2-furfural; Aes-103) is a breakdown product of glucose that has potent anti-sickling…