Adjuvanticity

the ability to nonspecifically stimulate the immune response.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot… (More)
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Highly Cited
2011
Highly Cited
2011
As an approved vaccine adjuvant for use in humans, alum has vast health implications, but, as it is a crystal, questions remain… (More)
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Highly Cited
2010
Highly Cited
2010
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent… (More)
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Highly Cited
2009
Highly Cited
2009
Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as… (More)
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Highly Cited
2008
Highly Cited
2008
The development of vaccine adjuvants for human use has been one of the slowest processes in the history of medicine. For almost… (More)
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Highly Cited
2008
Highly Cited
2008
Alum (aluminum hydroxide) is the most widely used adjuvant in human vaccines, but the mechanism of its adjuvanticity remains… (More)
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Highly Cited
1998
Highly Cited
1998
Heat-labile Escherichia coli enterotoxin (LT) has the innate property of being a strong mucosal immunogen and adjuvant. In the… (More)
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Highly Cited
1997
Highly Cited
1997
Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent… (More)
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Highly Cited
1995
Highly Cited
1995
The heat-labile enterotoxin (LT) of Escherichia coli is immunologically and physiochemically related to cholera enterotoxin. A… (More)
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Review
1993
Review
1993
Adjuvants have been used to augment the immune response in experimental immunology as well as in practical vaccination for more… (More)
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