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Adenylate Cyclase Toxin

Known as: Bordetella Ac-Hly, AC Toxin, Bordetella, Toxin, Bordetella AC 
One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin… 
National Institutes of Health

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Bordetella pertussis Adenylate Cyclase Toxin
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

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2014
2014
The Bordetella Adenylate Cyclase Repeat-in-Toxin (RTX) Domain Is Immunodominant and Elicits Neutralizing Antibodies*
Background: The protective antigen adenylate cyclase toxin (ACT) has not been included in current pertussis vaccines partly due… 
Highly Cited
2010
Highly Cited
2010
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.
Bordetella pertussis, the causative agent of whooping cough, secretes among various toxins an adenylate cyclase (CyaA) that… 
Highly Cited
2002
Highly Cited
2002
Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte‐derived dendritic cells and dominantly inhibit cytokine production through a cAMP‐dependent pathway
Pertussis toxin (PT) and adenylate cyclase toxin (AT) are AB enterotoxins produced by Bordetella pertussis. PT is a powerful… 
1999
1999
Adjuvant and protective properties of native and recombinant Bordetella pertussis adenylate cyclase toxin preparations in mice.
Bordetella pertussis produces a cell-invasive adenylate cyclase toxin which is synthesised from the cyaA gene as an inactive… 
1999
1999
Characterization of the C‐terminal domain essential for toxic activity of adenylate cyclase toxin
Adenylate cyclase toxin (CyaA) of Bordetella pertussis belongs to the RTX family of toxins. These toxins are characterized by a… 
Highly Cited
1996
Highly Cited
1996
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.
Exogenous Ags enter the endosomal pathway and are presented to CD4+ T cells in association with class II molecules whereas… 
Highly Cited
1995
Highly Cited
1995
Identification by in vitro complementation of regions required for cell‐invasive activity of Bordetella pertussis adenylate cyclase toxin
The adenylate cyclase toxin (CyaA) of Bordetella pertussis is a 1706‐residue protein composed of an amino‐terminal adenylate… 
Highly Cited
1995
Highly Cited
1995
Membrane Depolarization Prevents Cell Invasion by Bordetella pertussis Adenylate Cyclase Toxin(*)
Adenylate cyclase toxin from Bordetella pertussis is a 177-kDa calmodulin-activated enzyme that has the ability to enter… 
Highly Cited
1993
Highly Cited
1993
Identification of Bordetella pertussis in nasopharyngeal swabs by PCR amplification of a region of the adenylate cyclase gene.
The polymerase chain reaction (PCR) was used to amplify a 522-bp region of the adenylate cyclase toxin (cyaA) gene of Bordetella… 
Highly Cited
1992
Highly Cited
1992
Insertional mutagenesis of Bordetella pertussis adenylate cyclase.
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