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Adenylate Cyclase Toxin

Known as: Bordetella Ac-Hly, AC Toxin, Bordetella, Toxin, Bordetella AC 
One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin… 
National Institutes of Health

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Bordetella pertussis Adenylate Cyclase Toxin
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

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Highly Cited
2010
Highly Cited
2010
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.
Bordetella pertussis, the causative agent of whooping cough, secretes among various toxins an adenylate cyclase (CyaA) that… 
Highly Cited
2006
Highly Cited
2006
Structural and Functional Characterization of an Essential RTX Subdomain of Bordetella pertussis Adenylate Cyclase Toxin*
The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella pertussis, the causative agent of whooping… 
Highly Cited
2005
Highly Cited
2005
Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells.
The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers… 
Highly Cited
2004
Highly Cited
2004
Membrane Restructuring by Bordetella pertussis Adenylate Cyclase Toxin, a Member of the RTX Toxin Family
ABSTRACT Adenylate cyclase toxin (ACT) is secreted by Bordetella pertussis, the bacterium causing whooping cough. ACT is a member… 
Highly Cited
2003
Highly Cited
2003
Interaction of Bordetella pertussis Adenylate Cyclase with CD11b/CD18
Adenylate cyclase toxin (CyaA) is one of the major virulence factors produced by Bordetella pertussis, the whooping cough agent… 
Highly Cited
2000
Highly Cited
2000
Neutralizing Antibodies to Adenylate Cyclase Toxin Promote Phagocytosis of Bordetella pertussis by Human Neutrophils
ABSTRACT A previous study showed that opsonization with human immune serum could either promote or antagonize phagocytosis of… 
Highly Cited
1996
Highly Cited
1996
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.
Exogenous Ags enter the endosomal pathway and are presented to CD4+ T cells in association with class II molecules whereas… 
Highly Cited
1993
Highly Cited
1993
CyaC-mediated activation is important not only for toxic but also for protective activities of Bordetella pertussis adenylate cyclase-hemolysin
Bordetella pertussis adenylate cyclase-hemolysin (AC-Hly), encoded by the cyaA gene, belongs to the RTX family of toxins with… 
Highly Cited
1990
Highly Cited
1990
The Rhizobium nodulation gene nodO encodes a Ca2(+)‐binding protein that is exported without N‐terminal cleavage and is homologous to haemolysin and related proteins.
Nodulation and host‐specific recognition of legumes such as peas and Vicia spp. are encoded by the nodulation (nod) genes of… 
Highly Cited
1988
Highly Cited
1988
The calmodulin‐sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col
The adenylate cyclase toxin of the prokaryote Bordetella pertussis is stimulated by the eukaryotic regulatory protein, calmodulin… 
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