Adenovirus Encoding Human Aquaporin-1

Known as: AdhAQP1 
A replication-deficient, recombinant adenovirus encoding human aquaporin-1 with potential membrane water channel activity. Upon transfection of… Expand
National Institutes of Health

Papers overview

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2017
2017
Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction
We evaluated late effects of AdhAQP1 administration in five subjects in a clinical trial for radiation-induced salivary… Expand
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2016
2016
Hepatic gene transfer of human aquaporin-1 improves bile salt secretory failure in rats with estrogen-induced cholestasis.
UNLABELLED The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17α-ethinylestradiol-induced… Expand
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2010
2010
Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland.
BACKGROUND Radiation-induced salivary hypofunction is a common side-effect of treatment for head and neck cancers. Patients… Expand
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2006
2006
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
Before conducting a phase 1/2 clinical trial of a serotype 5 adenovirus encoding human aquaporin-1 (AdhAQP1) for the treatment of… Expand
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Review
2006
Review
2006
Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.
The treatment of most patients with head and neck cancer includes ionizing radiation (IR). Salivary glands in the IR field suffer… Expand
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2005
2005
Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands.
The treatment of most head and neck cancer patients includes ionizing radiation (IR). Salivary glands in the IR field suffer… Expand
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1999
1999
Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates
This study evaluated the safety and efficacy of a single administration of a recombinant adenovirus encoding human aquaporin-1… Expand
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1998
1998
Relationship between adenovirus-mediated aquaporin 1 expression and fluid movement across epithelial cells.
AdhAQP1, a recombinant adenovirus encoding the human water channel aquaporin 1 (AQP1), has been shown to be useful for gene… Expand
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1998
1998
Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo.
Aquaporin 1 (AQP1) is the archetypal member of a family of integral membrane proteins that function as water channels. Previously… Expand
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Highly Cited
1997
Highly Cited
1997
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands.
A replication-deficient, recombinant adenovirus encoding human aquaporin-1 (hAQP1), the archetypal water channel, was constructed… Expand
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