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Adenovirus Encoding Human Aquaporin-1

Known as: AdhAQP1 
A replication-deficient, recombinant adenovirus encoding human aquaporin-1 with potential membrane water channel activity. Upon transfection of… 
National Institutes of Health

Papers overview

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2015
2015
Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter
In 2012, we reported that 5 out of 11 subjects in a clinical trial (NCT00372320) administering AdhAQP1 to radiation-damaged… 
2012
2012
Behavior of periodontal cells with aquaporin-1 immunoreaction during experimental tooth movement
2007
2007
Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats.
We have examined the safety of a replication-deficient recombinant adenovirus administered at a single, high dose intraductally… 
2006
2006
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
Before conducting a phase 1/2 clinical trial of a serotype 5 adenovirus encoding human aquaporin-1 (AdhAQP1) for the treatment of… 
1998
1998
Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo.
Aquaporin 1 (AQP1) is the archetypal member of a family of integral membrane proteins that function as water channels. Previously… 
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