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Adenovirus Encoding Human Aquaporin-1

Known as: AdhAQP1 
A replication-deficient, recombinant adenovirus encoding human aquaporin-1 with potential membrane water channel activity. Upon transfection of… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Hepatic gene transfer of human aquaporin‐1 improves bile salt secretory failure in rats with estrogen‐induced cholestasis
The adenoviral gene transfer of human aquaporin‐1 (hAQP1) water channels to the liver of 17α‐ethinylestradiol‐induced cholestatic… 
2015
2015
Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter
In 2012, we reported that 5 out of 11 subjects in a clinical trial (NCT00372320) administering AdhAQP1 to radiation-damaged… 
2014
2014
Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen-induced cholestasis
Estrogens can cause liver cholestatic disease. As downregulation of hepatocyte canalicular aquaporin-8 (AQP8) water channels has… 
2012
2012
Behavior of periodontal cells with aquaporin-1 immunoreaction during experimental tooth movement
2010
2010
Transient detection of E1‐containing adenovirus in saliva after the delivery of a first‐generation adenoviral vector to human parotid gland
Radiation‐induced salivary hypofunction is a common side‐effect of treatment for head and neck cancers. Patients suffer… 
2007
2007
Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats.
We have examined the safety of a replication-deficient recombinant adenovirus administered at a single, high dose intraductally… 
2006
2006
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
Before conducting a phase 1/2 clinical trial of a serotype 5 adenovirus encoding human aquaporin-1 (AdhAQP1) for the treatment of… 
Highly Cited
1999
Highly Cited
1999
Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates
This study evaluated the safety and efficacy of a single administration of a recombinant adenovirus encoding human aquaporin-1… 
1998
1998
Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo.
Aquaporin 1 (AQP1) is the archetypal member of a family of integral membrane proteins that function as water channels. Previously… 
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