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Adenosylhomocysteinase, human
Known as:
Adenosylhomocysteinase
, S-Adenosylhomocysteine Hydrolase
, AHCY
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Adenosylhomocysteinase (432 aa, ~48 kDa) is encoded by the human AHCY gene. This protein plays a role in amino acid modification.
National Institutes of Health
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Related topics
Related topics
8 relations
AHCY gene
AHCY wt Allele
Amino Acid Biosynthesis
Cytoplasmic matrix
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Broader (1)
Adenosylhomocysteinase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Proteome changes induced by aluminium stress in tomato roots.
Suping Zhou
,
R. Sauvé
,
T. Thannhauser
Journal of Experimental Botany
2009
Corpus ID: 31016149
Growth inhibition in acid soils due to Al stress affects crop production worldwide. To understand mechanisms in sensitive crops…
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Review
2007
Review
2007
Structure and function of S-adenosylhomocysteine hydrolase
M. A. Turner
,
Xiaoda Yang
,
D. Yin
,
K. Kuczera
,
R. Borchardt
,
P. Howell
Cell Biochemistry and Biophysics
2007
Corpus ID: 26861989
In mammals, S-adenosylhomocysteine hydrolase (AdoHcyase) is the only known enzyme to catalyze the breakdown of S…
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Review
2004
Review
2004
S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action.
D. Kloor
,
H. Osswald
TIPS - Trends in Pharmacological Sciences
2004
Corpus ID: 31900426
2000
2000
Effects of Site-directed Mutagenesis on Structure and Function of Recombinant Rat Liver S-Adenosylhomocysteine Hydrolase
J. Komoto
,
Yafei Huang
,
+4 authors
F. Takusagawa
Journal of Biological Chemistry
2000
Corpus ID: 5627825
A site-directed mutagenesis, D244E, ofS-adenosylhomocysteine hydrolase (AdoHcyase) changes drastically the nature of the protein…
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Highly Cited
1999
Highly Cited
1999
Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Y. Hu
,
J. Komoto
,
+5 authors
F. Takusagawa
Biochemistry
1999
Corpus ID: 21811090
The crystal structure of rat liver S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) which catalyzes the reversible…
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1993
1993
Selective inhibition of T cell activation by an inhibitor of S-adenosyl-L-homocysteine hydrolase.
J. Wolos
,
K. Frondorf
,
G. F. Davis
,
E. Jarvi
,
J. Mccarthy
,
T. Bowlin
Journal of Immunology
1993
Corpus ID: 36007870
Defects in the enzymes involved in the pathway of S-adenosylmethionine (AdoMet) metabolism, or inhibition of those enzymes…
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Highly Cited
1992
Highly Cited
1992
Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy.
D. M. Henderson
,
S. Hanson
,
+5 authors
B. Ullman
Molecular and biochemical parasitology (Print)
1992
Corpus ID: 4019776
Highly Cited
1984
Highly Cited
1984
Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.
M. Hershfield
,
J. Kurtzberg
,
E. Harden
,
J. Moore
,
J. Whang‐Peng
,
B. Haynes
Proceedings of the National Academy of Sciences…
1984
Corpus ID: 22944213
Selective failure of lymphoid development occurs in genetic deficiency of adenosine deaminase (ADA). We examined the in vivo…
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Highly Cited
1980
Highly Cited
1980
Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.
M. Hershfield
,
N. M. Kredich
Proceedings of the National Academy of Sciences…
1980
Corpus ID: 44748125
Accumulation of dATP derived from 2'-deoxyadenosine (dAdo), causing inhibition of ribonucleotide reductase and depletion of the…
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Highly Cited
1971
Highly Cited
1971
Inhibition of transmethylations of biogenic amines by S-adenosylhomocysteine. Enhancement of transmethylation by adenosylhomocysteinase.
T. Deguchi
,
J. Barchas
Journal of Biological Chemistry
1971
Corpus ID: 21402271
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