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Adenosylhomocysteinase, human

Known as: Adenosylhomocysteinase, S-Adenosylhomocysteine Hydrolase, AHCY 
Adenosylhomocysteinase (432 aa, ~48 kDa) is encoded by the human AHCY gene. This protein plays a role in amino acid modification.
National Institutes of Health

Related topics

Related topics

8 relations
AHCY geneAHCY wt AlleleAmino Acid BiosynthesisCytoplasmic matrix

Broader (1)

Adenosylhomocysteinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
The network of non-coding RNAs and their molecular targets in breast cancer
Non-coding RNAs are now recognized as fundamental components of the cellular processes. Non-coding RNAs are composed of different… 
Review
2004
Review
2004
S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action.
2002
2002
Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
S-Adenosylhomocysteine hydrolase (AdoHcyase) catalyzes the hydrolysis of S-adenosylhomocysteine to form adenosine and… 
2000
2000
Effects of Site-directed Mutagenesis on Structure and Function of Recombinant Rat Liver S-Adenosylhomocysteine Hydrolase
A site-directed mutagenesis, D244E, ofS-adenosylhomocysteine hydrolase (AdoHcyase) changes drastically the nature of the protein… 
Highly Cited
1999
Highly Cited
1999
Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
The crystal structure of rat liver S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) which catalyzes the reversible… 
1993
1993
Selective inhibition of T cell activation by an inhibitor of S-adenosyl-L-homocysteine hydrolase.
Defects in the enzymes involved in the pathway of S-adenosylmethionine (AdoMet) metabolism, or inhibition of those enzymes… 
1992
1992
Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy.
1982
1982
Induction of rat liver glycine methyltransferase by high methionine diet.
Highly Cited
1980
Highly Cited
1980
Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.
Accumulation of dATP derived from 2'-deoxyadenosine (dAdo), causing inhibition of ribonucleotide reductase and depletion of the… 
Highly Cited
1971
Highly Cited
1971
Inhibition of transmethylations of biogenic amines by S-adenosylhomocysteine. Enhancement of transmethylation by adenosylhomocysteinase.
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