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Adenosylhomocysteinase, human

Known as: Adenosylhomocysteinase, S-Adenosylhomocysteine Hydrolase, AHCY 
Adenosylhomocysteinase (432 aa, ~48 kDa) is encoded by the human AHCY gene. This protein plays a role in amino acid modification.
National Institutes of Health

Related topics

Related topics

8 relations
AHCY geneAHCY wt AlleleAmino Acid BiosynthesisCytoplasmic matrix

Broader (1)

Adenosylhomocysteinase

Papers overview

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Highly Cited
2009
Highly Cited
2009
Proteome changes induced by aluminium stress in tomato roots.
Growth inhibition in acid soils due to Al stress affects crop production worldwide. To understand mechanisms in sensitive crops… 
Review
2007
Review
2007
Structure and function of S-adenosylhomocysteine hydrolase
In mammals, S-adenosylhomocysteine hydrolase (AdoHcyase) is the only known enzyme to catalyze the breakdown of S… 
Review
2004
Review
2004
S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action.
2000
2000
Effects of Site-directed Mutagenesis on Structure and Function of Recombinant Rat Liver S-Adenosylhomocysteine Hydrolase
A site-directed mutagenesis, D244E, ofS-adenosylhomocysteine hydrolase (AdoHcyase) changes drastically the nature of the protein… 
Highly Cited
1999
Highly Cited
1999
Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
The crystal structure of rat liver S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) which catalyzes the reversible… 
1993
1993
Selective inhibition of T cell activation by an inhibitor of S-adenosyl-L-homocysteine hydrolase.
Defects in the enzymes involved in the pathway of S-adenosylmethionine (AdoMet) metabolism, or inhibition of those enzymes… 
Highly Cited
1992
Highly Cited
1992
Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy.
Highly Cited
1984
Highly Cited
1984
Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.
Selective failure of lymphoid development occurs in genetic deficiency of adenosine deaminase (ADA). We examined the in vivo… 
Highly Cited
1980
Highly Cited
1980
Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.
Accumulation of dATP derived from 2'-deoxyadenosine (dAdo), causing inhibition of ribonucleotide reductase and depletion of the… 
Highly Cited
1971
Highly Cited
1971
Inhibition of transmethylations of biogenic amines by S-adenosylhomocysteine. Enhancement of transmethylation by adenosylhomocysteinase.
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