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Adaptive Design

Known as: ADAPT 
A study design which includes a prospectively planned opportunity for modification of one or more specified aspects of the study design and/or… 
National Institutes of Health

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CDISC SDTM Trial Summary Parameter Terminology by CodeCDISC SDTM Trial Summary Parameter Terminology by NameClinical Data Interchange Standards Consortium Terminology

Papers overview

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Review
2018
Review
2018
Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials
Abstract Objective Adaptive designs can enable highly sophisticated and efficient early phase trials, but the clinical inference… 
Review
2017
Review
2017
LUME-Meso: Design and Rationale of the Phase III Part of a Placebo-Controlled Study of Nintedanib and Pemetrexed/Cisplatin Followed by Maintenance Nintedanib in Patients With Unresectable Malignant…
Review
2017
Review
2017
DIA’s Adaptive Design Scientific Working Group (ADSWG): Best Practices Case Studies for “Less Well-understood” Adaptive Designs
Adaptive design (AD) clinical trials use accumulating subject data to modify the parameters of the design of an ongoing study… 
2014
2014
EXTENSION ADAPTIVE DESIGN MODEL OF SCHEME DESIGN FOR COMPLEX MECHANICAL PRODUCTS
Original scientific paper Due to the complicated, multi-hierarchy, multi-attribute and creative process of product structure… 
2011
2011
Optimization of UWB planar antennas using adaptive design specifications
A simulation-driven optimization framework for computationally efficient design of ultrawideband (UWB) antennas is presented. Our… 
2011
2011
Sample size re‐estimation for survival data in clinical trials with an adaptive design
In clinical trials with survival data, investigators may wish to re‐estimate the sample size based on the observed effect size… 
2010
2010
Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials
A two‐stage adaptive design trial is a single trial that combines the learning data from stage 1 (or phase II) and the confirming… 
2005
2005
A Hybrid Bayesian Adaptive Design for Dose Response Trials
ABSTRACT In recent years, the use of adaptive design methods based on accrued data of on-going trials have become very popular… 
2005
2005
Two-Stage Adaptive Design for Clinical Trials with Survival Data
Abstract In long-term clinical trials we often need to monitor the patients’ enrollment, compliance, and treatment effect during… 
2000
2000
Analysis of time trends in adaptive designs with application to a neurophysiology experiment.
Time trends are present in many sequential experiments. Adaptive designs use accruing data to select future design points. It has… 
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