Acyclovir

Known as: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one, Aciclovir, 9-[(2-Hydroxyethoxy)methyl]guanine 
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster… (More)
National Institutes of Health

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6-deoxypenciclovir9-(4-hydroxybutyl)guanineAci-SanoraniaAcyclo-V
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Acyclovir 200 MG Oral CapsuleAcyclovir 200 MG Oral Capsule [Zovirax]Acyclovir 400 MG Oral Tablet [Zovirax]Acyclovir 800 MG Oral Tablet
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
BACKGROUND—Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex… (More)
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Review
2003
Review
2003
Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy.
Acyclovir, penciclovir, and their prodrugs have been widely used during the past two decades for the treatment of herpesvirus… (More)
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Highly Cited
2001
Highly Cited
2001
Natural history of neonatal herpes simplex virus infections in the acyclovir era.
OBJECTIVE During the 2 decades in which effective antiviral therapies have been available for neonatal herpes simplex virus (HSV… (More)
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Highly Cited
2001
Highly Cited
2001
Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections.
OBJECTIVE The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of… (More)
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Highly Cited
1997
Highly Cited
1997
Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment.
Reactivation of herpes simplex virus type 2 (HSV-2) occurs intermittently as perceived clinically and by viral culture. We… (More)
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Highly Cited
1995
Highly Cited
1995
Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults.
Acyclovir treatment of acute herpes zoster speeds rash healing and decreases pain and ocular complications. The limited oral… (More)
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Highly Cited
1993
Highly Cited
1993
Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers.
The pharmacokinetics and safety of the L-valyl ester pro-drug of acyclovir, valaciclovir (256U87), were investigated in two phase… (More)
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Highly Cited
1988
Highly Cited
1988
Acyclovir for prevention of cytomegalovirus infection and disease after allogeneic marrow transplantation.
Patients undergoing allogeneic bone marrow transplantation who are seropositive for cytomegalovirus are vulnerable to serious… (More)
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Highly Cited
1986
Highly Cited
1986
Vidarabine versus acyclovir therapy in herpes simplex encephalitis.
We randomly assigned 208 patients who underwent brain biopsy for presumptive herpes simplex encephalitis to receive either… (More)
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Highly Cited
1981
Highly Cited
1981
Acyclovir prophylaxis of herpes-simplex-virus infections.
We conducted a double-blind, placebo-controlled study of acyclovir prophylaxis against infection with herpes simplex virus (HSV… (More)
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