Acyclovir

Known as: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one, Aciclovir, 9-[(2-Hydroxyethoxy)methyl]guanine 
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND—Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex… (More)
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Review
2003
Review
2003
Acyclovir, penciclovir, and their prodrugs have been widely used during the past two decades for the treatment of herpesvirus… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE During the 2 decades in which effective antiviral therapies have been available for neonatal herpes simplex virus (HSV… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of… (More)
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Highly Cited
1997
Highly Cited
1997
Reactivation of herpes simplex virus type 2 (HSV-2) occurs intermittently as perceived clinically and by viral culture. We… (More)
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Highly Cited
1995
Highly Cited
1995
Acyclovir treatment of acute herpes zoster speeds rash healing and decreases pain and ocular complications. The limited oral… (More)
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Highly Cited
1993
Highly Cited
1993
The pharmacokinetics and safety of the L-valyl ester pro-drug of acyclovir, valaciclovir (256U87), were investigated in two phase… (More)
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Highly Cited
1988
Highly Cited
1988
Patients undergoing allogeneic bone marrow transplantation who are seropositive for cytomegalovirus are vulnerable to serious… (More)
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Highly Cited
1986
Highly Cited
1986
We randomly assigned 208 patients who underwent brain biopsy for presumptive herpes simplex encephalitis to receive either… (More)
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Highly Cited
1981
Highly Cited
1981
We conducted a double-blind, placebo-controlled study of acyclovir prophylaxis against infection with herpes simplex virus (HSV… (More)
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