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AcrAB-TolC complex
Known as:
AcrAB-TolC complex location
National Institutes of Health
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Highly Cited
2017
Highly Cited
2017
Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae
O. Lomovskaya
,
Dongxu Sun
,
+4 authors
M. Dudley
Antimicrobial Agents and Chemotherapy
2017
Corpus ID: 13416913
ABSTRACT Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore. The…
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Review
2015
Review
2015
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
Xian-Zhi Li
,
P. Plésiat
,
H. Nikaido
Clinical Microbiology Reviews
2015
Corpus ID: 10572239
SUMMARY The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic therapy. The…
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Highly Cited
2014
Highly Cited
2014
Properties of AdeABC and AdeIJK Efflux Systems of Acinetobacter baumannii Compared with Those of the AcrAB-TolC System of Escherichia coli
E. Sugawara
,
H. Nikaido
Antimicrobial Agents and Chemotherapy
2014
Corpus ID: 21364531
ABSTRACT Acinetobacter baumannii contains RND-family efflux systems AdeABC and AdeIJK, which pump out a wide range of…
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Review
2013
Review
2013
RND efflux pumps: structural information translated into function and inhibition mechanisms.
P. Ruggerone
,
S. Murakami
,
K. M. Pos
,
A. Vargiu
Current Topics in Medicinal Chemistry
2013
Corpus ID: 35600008
Efflux pumps of the Resistance Nodulation Division (RND) superfamily play a major role in the intrinsic and acquired resistance…
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Review
2012
Review
2012
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.
H. Nikaido
,
J. Pagés
FEMS Microbiology Reviews
2012
Corpus ID: 35456832
Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a worldwide health problem. The continuous…
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Highly Cited
2009
Highly Cited
2009
Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli
L. Paixão
,
L. Rodrigues
,
+7 authors
M. Viveiros
Journal of Biological Engineering
2009
Corpus ID: 1452383
BackgroundEfflux pump activity has been associated with multidrug resistance phenotypes in bacteria, compromising the…
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Highly Cited
2009
Highly Cited
2009
The Global Consequence of Disruption of the AcrAB-TolC Efflux Pump in Salmonella enterica Includes Reduced Expression of SPI-1 and Other Attributes Required To Infect the Host
M. Webber
,
A. Bailey
,
+6 authors
L. Piddock
Journal of Bacteriology
2009
Corpus ID: 12552957
ABSTRACT The mechanisms by which RND pumps contribute to pathogenicity are currently not understood. Using the AcrAB-TolC system…
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Review
2006
Review
2006
Quinoline derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes isolates.
A. Mahamoud
,
J. Chevalier
,
A. Davin-Régli
,
J. Barbe
,
J. Pagés
Current Drug Targets
2006
Corpus ID: 40635618
Efflux pumps protect the bacterial cell by expelling toxic compounds before they reach intracellular targets. Because this…
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Highly Cited
2004
Highly Cited
2004
AcrAB-TolC Directs Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium DT104
Sylvie Baucheron
,
S. Tyler
,
D. Boyd
,
M. Mulvey
,
É. Chaslus-Dancla
,
A. Cloeckaert
Antimicrobial Agents and Chemotherapy
2004
Corpus ID: 43399507
ABSTRACT Multidrug-resistant Salmonella enterica serovar Typhimurium definitive phage type 104 (DT104) strains harbor a genomic…
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Highly Cited
2002
Highly Cited
2002
The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204.
Sylvie Baucheron
,
H. Imberechts
,
É. Chaslus-Dancla
,
A. Cloeckaert
Microbial Drug Resistance
2002
Corpus ID: 8166064
Salmonella enterica serovar Typhimurium phage type DT204 strains isolated from cattle and animal feed in Belgium were…
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