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AcrAB-TolC complex

Known as: AcrAB-TolC complex location 
 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae
ABSTRACT Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore. The… Expand
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Review
2015
Review
2015
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
SUMMARY The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic therapy. The… Expand
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Highly Cited
2014
Highly Cited
2014
Properties of AdeABC and AdeIJK Efflux Systems of Acinetobacter baumannii Compared with Those of the AcrAB-TolC System of Escherichia coli
ABSTRACT Acinetobacter baumannii contains RND-family efflux systems AdeABC and AdeIJK, which pump out a wide range of… Expand
Review
2012
Review
2012
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.
Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a worldwide health problem. The continuous… Expand
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Highly Cited
2009
Highly Cited
2009
Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli
BackgroundEfflux pump activity has been associated with multidrug resistance phenotypes in bacteria, compromising the… Expand
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Highly Cited
2009
Highly Cited
2009
The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host.
The mechanisms by which RND pumps contribute to pathogenicity are currently not understood. Using the AcrAB-TolC system as a… Expand
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Review
2006
Review
2006
Quinoline derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes isolates.
Efflux pumps protect the bacterial cell by expelling toxic compounds before they reach intracellular targets. Because this… Expand
Highly Cited
2005
Highly Cited
2005
Overexpression of the Multidrug Efflux Operon acrEF by Insertional Activation with IS1 or IS10 Elements in Salmonella enterica Serovar Typhimurium DT204 acrB Mutants Selected with Fluoroquinolones
ABSTRACT High-level fluoroquinolone (FQ) resistance in Salmonella enterica serovar Typhimurium phage type DT204 has been… Expand
Highly Cited
2004
Highly Cited
2004
AcrAB-TolC Directs Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium DT104
ABSTRACT Multidrug-resistant Salmonella enterica serovar Typhimurium definitive phage type 104 (DT104) strains harbor a genomic… Expand
Highly Cited
2002
Highly Cited
2002
The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204.
Salmonella enterica serovar Typhimurium phage type DT204 strains isolated from cattle and animal feed in Belgium were… Expand
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