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AZD8330
Known as:
ARRY-424704
, ARRY-704
, MEK Inhibitor AZD8330
An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Dihydropyridines
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
B7-H6 Promotes Cell Proliferation, Migration and Invasion of Non-Hodgkin Lymphoma via Ras/MEK/ERK Pathway Based on Quantitative Phosphoproteomics Data
Siyuan Yang
,
Lei Yuan
,
Yanfang Wang
,
Mingxia Zhu
,
Jing Wang
,
X. Ke
OncoTargets and therapy
2020
Corpus ID: 220251409
Purpose B7 homologue 6 (B7-H6) has been found at an up-regulated level in multiple cancer cells and identified to be positively…
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2018
2018
TRIM65 is a potential oncogenic protein via ERK1/2 on Jurkat and Raji cells: A therapeutic target in human lymphoma malignancies
Jin Wang
,
Xue Liang
,
+6 authors
Shu He
Cell biology international
2018
Corpus ID: 51711385
In human lung cancer, Tripartite motif 65 (TRIM65) is documented as an important regulator in carcinogenesis. Knockdown of TRIM65…
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2017
2017
Chemical-biology approach to delineate the mechanism of action of HIV-1 latency reversing agents
Feng Qi Han
2017
Corpus ID: 51801902
Prostratin exhibits potent HIV-1 latency reversing activity, yet its molecular mechanism of action has not been defined in detail…
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2015
2015
MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation
Z. Baranski
,
T. H. Booij
,
+7 authors
E. Danen
Genes & cancer
2015
Corpus ID: 18896794
Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people…
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2015
2015
[Effect of ERK1/2 inhibitor AZD8330 on human Burkitt's lymphoma cell line Raji cells and its mechanism].
K. Feng
,
Chao Wang
,
+5 authors
Yongping Song
Zhonghua xue ye xue za zhi = Zhonghua xueyexue…
2015
Corpus ID: 39328369
OBJECTIVE To investigate the effect of ERK1/2 inhibitor AZD8330 on human Burkitt's lymphoma cell line Raji cells and its…
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Review
2014
Review
2014
MEK1/2 inhibitors in the treatment of gynecologic malignancies.
Caela R. Miller
,
K. Oliver
,
J. Farley
Gynecologic oncology
2014
Corpus ID: 205797901
2014
2014
[Effect of AZD8330 on proliferation and apoptosis of multiple myeloma cells].
Yao Yao
,
Yueping Bian
,
+5 authors
Kailin Xu
Zhongguo shi yan xue ye xue za zhi
2014
Corpus ID: 11247816
This study was aimed to investigate the effect of MEK inhibitor AZD8330 on proliferation and apoptosis of multiple myeloma IM9…
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Review
2013
Review
2013
MEK and the inhibitors: from bench to bedside
Akintunde Akinleye
,
M. Furqan
,
Nikhil Mukhi
,
P. Ravella
,
Delong Liu
Journal of Hematology & Oncology
2013
Corpus ID: 13210265
Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members…
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2013
2013
A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies.
R. Cohen
,
S. Aamdal
,
+5 authors
R. Kurzrock
European journal of cancer
2013
Corpus ID: 9059213
2009
2009
Abstract #3696: AZD8330 (ARRY-424704): Preclinical evaluation of a potent, selective MEK 1/2 inhibitor currently in phase I trials
E. Wallace
,
J. Lyssikatos
,
+20 authors
David M Robinson
2009
Corpus ID: 80074230
The dual-specificity kinases MEK 1/2 play key roles in tumorgenesis by activating the serine/threonine kinases ERK 1/2. These…
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