FAQ

AZD8330

Known as: ARRY-424704, ARRY-704, MEK Inhibitor AZD8330 
An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated… (More)

Topic mentions per year

Topic mentions per year

2013-2015
01220132015

Related topics

Related topics

1 relation

Broader (1)

Dihydropyridines

Related mentions per year

Related mentions per year

1951-2018
1960198020002020
AZD8330
Dihydropyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation
Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
[Effect of ERK1/2 inhibitor AZD8330 on human Burkitt's lymphoma cell line Raji cells and its mechanism].
OBJECTIVE To investigate the effect of ERK1/2 inhibitor AZD8330 on human Burkitt's lymphoma cell line Raji cells and its… (More)
Is this relevant?
2014
2014
[Effect of AZD8330 on proliferation and apoptosis of multiple myeloma cells].
This study was aimed to investigate the effect of MEK inhibitor AZD8330 on proliferation and apoptosis of multiple myeloma IM9… (More)
Is this relevant?
Review
2014
Review
2014
MEK1/2 inhibitors in the treatment of gynecologic malignancies.
Mitogen-activated protein kinases (MAPKs) are a family of ubiquitous eukaryotic signal transduction enzymes which link… (More)
  • figure 1
  • figure 2
  • table 1
Is this relevant?
2013
2013
A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies.
OBJECTIVE This is the first clinical study of the MEK1/2 inhibitor AZD8330 (ARRY-424704). This phase I study defined the maximum… (More)
Is this relevant?
Review
2013
Review
2013
MEK and the inhibitors: from bench to bedside
Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?